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| | N,N-dimethyl-1-(4-nitrophenyl)methanamine Basic information |
| | N,N-dimethyl-1-(4-nitrophenyl)methanamine Chemical Properties |
| Melting point | 118-119 °C | | Boiling point | 146-148 °C(Press: 18 Torr) | | density | 1.141±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 7.93±0.28(Predicted) | | Appearance | Light yellow to brown Liquid |
| | N,N-dimethyl-1-(4-nitrophenyl)methanamine Usage And Synthesis |
| Synthesis Reference(s) | The Journal of Organic Chemistry, 38, p. 912, 1973 DOI: 10.1021/jo00945a015
Synthetic Communications, 12, p. 801, 1982 DOI: 10.1080/00397918208061920 | | Synthesis | To a solution of 4-nitrobenzyl bromide (10.8 g, 0.05 mol) in acetonitrile (50 mL) was added an excess of dimethylamine (50 mL) and stirred at room temperature for 3 hours. Upon completion of the reaction, water (100 mL) was added to dilute the reaction mixture, which was subsequently extracted twice with dichloromethane (CH2Cl2, 2 x 50 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the target product N,N-dimethyl-4-nitrobenzylamine. | | References | [1] Medicinal Chemistry, 2016, vol. 12, # 5, p. 489 - 498
[2] European Journal of Medicinal Chemistry, 2014, vol. 86, p. 257 - 269
[3] Archiv der Pharmazie, 2014, vol. 347, # 12, p. 936 - 949
[4] Patent: WO2006/123145, 2006, A1. Location in patent: Page/Page column 58
[5] Journal of the American Chemical Society, 1983, vol. 105, # 13, p. 4136 - 4142 |
| | N,N-dimethyl-1-(4-nitrophenyl)methanamine Preparation Products And Raw materials |
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