2(1H)-Isoquinolinepropanenitrile, 5-[[4-[[4-(1,6-dihydro-1,4,5-trimethyl-6-oxo-3-pyridinyl)-2,6-dimethoxyphenyl]methyl]-1-piperazinyl]methyl]-3,4-dihydro-1-methyl-β-oxo-α-[[4-(trifluoromethyl)-2-thiazolyl]methylene]-

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2(1H)-Isoquinolinepropanenitrile, 5-[[4-[[4-(1,6-dihydro-1,4,5-trimethyl-6-oxo-3-pyridinyl)-2,6-dimethoxyphenyl]methyl]-1-piperazinyl]methyl]-3,4-dihydro-1-methyl-β-oxo-α-[[4-(trifluoromethyl)-2-thiazolyl]methylene]- Suppliers list
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2(1H)-Isoquinolinepropanenitrile, 5-[[4-[[4-(1,6-dihydro-1,4,5-trimethyl-6-oxo-3-pyridinyl)-2,6-dimethoxyphenyl]methyl]-1-piperazinyl]methyl]-3,4-dihydro-1-methyl-β-oxo-α-[[4-(trifluoromethyl)-2-thiazolyl]methylene]- Basic information
Product Name:2(1H)-Isoquinolinepropanenitrile, 5-[[4-[[4-(1,6-dihydro-1,4,5-trimethyl-6-oxo-3-pyridinyl)-2,6-dimethoxyphenyl]methyl]-1-piperazinyl]methyl]-3,4-dihydro-1-methyl-β-oxo-α-[[4-(trifluoromethyl)-2-thiazolyl]methylene]-
Synonyms:2(1H)-Isoquinolinepropanenitrile, 5-[[4-[[4-(1,6-dihydro-1,4,5-trimethyl-6-oxo-3-pyridinyl)-2,6-dimethoxyphenyl]methyl]-1-piperazinyl]methyl]-3,4-dihydro-1-methyl-β-oxo-α-[[4-(trifluoromethyl)-2-thiazolyl]methylene]-;BRD9 Degrader-2;Amphista Therapeutics' BRD9 Degrader (Compound B11)
CAS:3033018-68-4
MF:C40H43F3N6O4S
MW:760.87
EINECS:
Product Categories:
Mol File:3033018-68-4.mol
2(1H)-Isoquinolinepropanenitrile, 5-[[4-[[4-(1,6-dihydro-1,4,5-trimethyl-6-oxo-3-pyridinyl)-2,6-dimethoxyphenyl]methyl]-1-piperazinyl]methyl]-3,4-dihydro-1-methyl-β-oxo-α-[[4-(trifluoromethyl)-2-thiazolyl]methylene]- Structure
2(1H)-Isoquinolinepropanenitrile, 5-[[4-[[4-(1,6-dihydro-1,4,5-trimethyl-6-oxo-3-pyridinyl)-2,6-dimethoxyphenyl]methyl]-1-piperazinyl]methyl]-3,4-dihydro-1-methyl-β-oxo-α-[[4-(trifluoromethyl)-2-thiazolyl]methylene]- Chemical Properties
Boiling point 856.3±75.0 °C(predicted)
density 1.297±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka6.66±0.10(predicted)
Safety Information
MSDS Information
2(1H)-Isoquinolinepropanenitrile, 5-[[4-[[4-(1,6-dihydro-1,4,5-trimethyl-6-oxo-3-pyridinyl)-2,6-dimethoxyphenyl]methyl]-1-piperazinyl]methyl]-3,4-dihydro-1-methyl-β-oxo-α-[[4-(trifluoromethyl)-2-thiazolyl]methylene]- Usage And Synthesis
UsesBRD9 Degrader-2 (Compound B11) is a BRD9 degrader (DC50 ≤1.25 nM; Dmax≥75%). BRD9 Degrader-2 can be used for research of cancers[1].
IC 50BRD9: <1.25 nM (DC50)
References[1] David MCGARRY, et al. Compounds for targeted protein degradation. Patent. WO2024057021A1
2(1H)-Isoquinolinepropanenitrile, 5-[[4-[[4-(1,6-dihydro-1,4,5-trimethyl-6-oxo-3-pyridinyl)-2,6-dimethoxyphenyl]methyl]-1-piperazinyl]methyl]-3,4-dihydro-1-methyl-β-oxo-α-[[4-(trifluoromethyl)-2-thiazolyl]methylene]- Preparation Products And Raw materials
Tag:2(1H)-Isoquinolinepropanenitrile, 5-[[4-[[4-(1,6-dihydro-1,4,5-trimethyl-6-oxo-3-pyridinyl)-2,6-dimethoxyphenyl]methyl]-1-piperazinyl]methyl]-3,4-dihydro-1-methyl-β-oxo-α-[[4-(trifluoromethyl)-2-thiazolyl]methylene]-(3033018-68-4) Related Product Information
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