TM38837

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TM38837 Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
TM38837 Basic information
Product Name:TM38837
Synonyms:1H-Pyrazole-3-carboxamide, 1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-(2H-tetrazol-5-ylmethyl)-N-[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl]-
CAS:1034264-77-1
MF:C27H20Cl2F3N7O
MW:586.4
EINECS:
Product Categories:
Mol File:1034264-77-1.mol
TM38837 Structure
TM38837 Chemical Properties
density 1.496±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka4.371±0.10(predicted)
Safety Information
MSDS Information
TM38837 Usage And Synthesis
UsesCB1 antagonist 4 is a inverse agonist of cannabinoid receptor 1 (CB1) with an IC50 of 0.4 nM. CB1 antagonist 4 can reduce body weight, improve plasma inflammatory markers and glucose homeostasis[1].
IC 50CB1
References[1] Hgberg T, et al. Optimizing and characterizing 4-methyl substituted pyrazol-3-carboxamides leading to the peripheral cannabinoid 1 receptor inverse agonist TM38837. Bioorg Med Chem Lett. 2023 Dec 1;98:129572. DOI:10.1016/j.bmcl.2023.129572
TM38837 Preparation Products And Raw materials
Tag:TM38837(1034264-77-1) Related Product Information
2-Linoleoyl-rac-glycerol N-[[[[(4S)-3-(4-Chlorophenyl)-4,5-dihydro-4-phenyl-1H-pyrazol-1-yl][[[4-(trifluoromethyl)phenyl]sulfonyl]amino]methylene]amino]iminomethyl]acetamide 1-(2,3-Dichlorobenzoyl)-5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]-1H-indole Pregnenolone Dehydroabietylamine AM 251