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| | 6-BROMO-2-METHYL-3,4-DIHYDROQUINAZOLIN-4-ONE Basic information |
| Product Name: | 6-BROMO-2-METHYL-3,4-DIHYDROQUINAZOLIN-4-ONE | | Synonyms: | 6-BROMO-2-METHYL-3,4-DIHYDROQUINAZOLIN-4-ONE;6-bromo-2-methyl-1H-quinazolin-4-one;6-bromo-2-methylquinazolin-4(3H)-one(SALTDATA: FREE);6-broMo-2-Methylquinazolin-4-ol;6-bromo-2-methylquinazolin-4(1H)-one;6-bromo-2-methyl-4(3H)-Quinazolinone;4(1H)-Quinazolinone, 6-bromo-2-methyl-;4(3H)-Quinazolinone, 6-bromo-2-methyl- | | CAS: | 5426-59-5 | | MF: | C9H7BrN2O | | MW: | 239.07 | | EINECS: | | | Product Categories: | | | Mol File: | 5426-59-5.mol |  |
| | 6-BROMO-2-METHYL-3,4-DIHYDROQUINAZOLIN-4-ONE Chemical Properties |
| Melting point | 298 °C | | Boiling point | 372.6±44.0 °C(Predicted) | | density | 1.72±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 1.96±0.20(Predicted) | | Appearance | Off-white to light brown Solid |
| Risk Statements | 22 | | Safety Statements | 36/37 | | HS Code | 29339900 |
| | 6-BROMO-2-METHYL-3,4-DIHYDROQUINAZOLIN-4-ONE Usage And Synthesis |
| Chemical Properties | Light yellow solid | | Synthesis | The general procedure for the synthesis of 6-bromo-2-methylquinazolin-4(3H)-one from ethanoic anhydride and 2-amino-5-bromobenzoic acid was as follows: first, 2-amino-5-bromobenzoic acid was refluxed for 1 h in liquid ammonia (10 mL/g). Subsequently, the reaction solution was concentrated to a smaller volume and the residue was mixed with acetic anhydride (2 mL/g) and refluxing was continued for 4 hours. Upon completion of the reaction, water was added to the mixture and boiled for 30 minutes, followed by dropwise addition of 20% sodium hydroxide solution until a clarified solution was formed. Next, ammonium carbonate was added to the hot solution until a precipitate was formed. The mixture was allowed to stand at 4°C for 16 hours, after which the precipitate was collected by filtration, washed with water and finally dried under vacuum to give the target product in about 60% yield. | | References | [1] Patent: US2009/69320, 2009, A1. Location in patent: Page/Page column 76
[2] Journal of the American Chemical Society, 1906, vol. 28, p. 101 |
| | 6-BROMO-2-METHYL-3,4-DIHYDROQUINAZOLIN-4-ONE Preparation Products And Raw materials |
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