| Company Name: |
NCE Biomedical Co.,Ltd. |
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4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
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| Company Name: |
SPIRO PHARMA |
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| Email: |
eric_feng1954@126.com |
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| | Tesetaxel Basic information |
| Product Name: | Tesetaxel | | Synonyms: | Tesetaxel;DJ 927;2-Pyridinepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-3-fluoro-α-hydroxy-, (2aS,2bR,3S,4S,6S,8aR,10S,11aS,11bR,13aR)-2a-(acetyloxy)-3-(benzoyloxy)-10-[(dimethylamino)methyl]-2a,2b,3,4,5,6,8a,11a,11b,12,13,13a-dodecahydro-4-hydroxy-7,11b,14,14-tetramethyl-4,8-methano-2H-oxeto[3'',2'':3',4...;(2aS,2bR,3S,4S,6S,8aR,10R,11aS,11bR,13aR)-2a-acetoxy-6-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-3-(3-fluoropyridin-2-yl)-2-hydroxypropanoyl)oxy)-10-((dimethylamino)methyl)-4-hydroxy-7,11b,14,14-tetramethyl-2a,2b,3,4,5,6,8a,11a,11b,12,13,13a-dodecahydro-2H-4,8-methanooxeto[3'',2'':3',4']benzo[1',2':3,4]cyclodeca[1,2-d][1,3]dioxol-3-yl benzoate | | CAS: | 333754-36-2 | | MF: | C46H60FN3O13 | | MW: | 881.99 | | EINECS: | | | Product Categories: | | | Mol File: | 333754-36-2.mol |  |
| | Tesetaxel Chemical Properties |
| Melting point | 147-149 °C | | Boiling point | 880.5±65.0 °C(Predicted) | | density | 1.34±0.1 g/cm3(Predicted) | | pka | 10.17±0.46(Predicted) |
| | Tesetaxel Usage And Synthesis |
| Uses | Tesetaxel is a orally active, semisynthetic microtubule inhibitor of the taxane class for the research of cancer, including colorectal and gastric cancer. | | References | [1] Shionoya M, Jimbo T, Kitagawa M, Soga T, Tohgo A. DJ-927, a novel oral taxane, overcomes P-glycoprotein-mediated multidrug resistance in vitro and in vivo. Cancer Sci. 2003;94(5):459-466. DOI:10.1111/j.1349-7006.2003.tb01465.x
[2] Saif MW, Sarantopoulos J, Patnaik A, Tolcher AW, Takimoto C, Beeram M. Tesetaxel, a new oral taxane, in combination with capecitabine: a phase I, dose-escalation study in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2011;68(6):1565-1573. DOI:10.1007/s00280-011-1639-3 |
| | Tesetaxel Preparation Products And Raw materials |
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