1-Arachidoyl-2-hydroxy-sn-glycero-3-PA (sodium salt)

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1-Arachidoyl-2-hydroxy-sn-glycero-3-PA (sodium salt) Basic information
Product Name:1-Arachidoyl-2-hydroxy-sn-glycero-3-PA (sodium salt)
Synonyms:1-Arachidoyl-2-hydroxy-sn-glycero-3-PA (sodium salt)
CAS:
MF:
MW:0
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Mol File:Mol File
1-Arachidoyl-2-hydroxy-sn-glycero-3-PA (sodium salt) Structure
1-Arachidoyl-2-hydroxy-sn-glycero-3-PA (sodium salt) Chemical Properties
solubility Methanol: Soluble
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MSDS Information
1-Arachidoyl-2-hydroxy-sn-glycero-3-PA (sodium salt) Usage And Synthesis
Description1-Arachidoyl-2-hydroxy-sn-glycero-3-PA (1-arachidoyl LPA) is an agonist of lysophosphatidic acid receptor 1 (LPA1) and a glycerophospholipid containing arachidic acid (Item Nos. 9000339 | 21906) at the sn-1 position.1 It induces calcium mobilization in primary human lung fibroblasts (EC50 = 3.6 µM), which endogenously express LPA1 but not LPA2-LPA6. 1-Arachidoyl LPA (2.5 µM) also binds to the ligand-binding domain of peroxisome proliferator-activated receptor γ (PPARγ) in a cell-free assay.2 It has been found in human urine.3WARNING This product is not for human or veterinary use.
References[1] AFRAH SATTIKAR  Elizabeth M R  Mark R Dowling. Endogenous lysophosphatidic acid (LPA1) receptor agonists demonstrate ligand bias between calcium and ERK signalling pathways in human lung fibroblasts[J]. British Journal of Pharmacology, 2016, 174 3: 227-237. DOI: 10.1111/bph.13671
[2] TAMOTSU TSUKAHARA. Different residues mediate recognition of 1-O-oleyllysophosphatidic acid and rosiglitazone in the ligand binding domain of peroxisome proliferator-activated receptor gamma.[J]. The Journal of Biological Chemistry, 2006, 281 6: 3398-3407. DOI: 10.1074/jbc.m510843200
[3] SANGSOO LIM. Computational approach to structural identification of phospholipids using raw mass spectra from nanoflow liquid chromatography–electrospray ionization–tandem mass spectrometry[J]. Journal of Mass Spectrometry, 2012, 47 8: 1004-1014. DOI: 10.1002/jms.3033
1-Arachidoyl-2-hydroxy-sn-glycero-3-PA (sodium salt) Preparation Products And Raw materials
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