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| | N-(6-Aminohexyl)maleimide trifluoroacetate salt Basic information |
| Product Name: | N-(6-Aminohexyl)maleimide trifluoroacetate salt | | Synonyms: | 1-(6-Aminohexyl);Mal-C6-amine TFA salt;1-(6-Aminohexyl)-1H-pyrrole-2,5-dione 2,2,2-trifluoroacetate;N-(6-Aminohexyl)maleimide trifluoroacetate salt;Mal-C6-amine TFA;N-(6-Aminohexyl)maleimide trifluoroacetate | | CAS: | 731862-92-3 | | MF: | C12H17F3N2O4 | | MW: | 310.27 | | EINECS: | | | Product Categories: | | | Mol File: | 731862-92-3.mol |  |
| | N-(6-Aminohexyl)maleimide trifluoroacetate salt Chemical Properties |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | form | Solid | | color | Off-white to light yellow |
| | N-(6-Aminohexyl)maleimide trifluoroacetate salt Usage And Synthesis |
| Description | Mal-C6-amine TFA salt contains maleimide and amine end groups. Maleimides are react with thiol groups and form thiolester bonds between pH 6.5 to 7.5. The primary amine can react with carboxylic acids, activated NHS esters and other carbonyl compounds. | | Uses | Mal-C6-amine (TFA) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | Alkyl-Chain | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | N-(6-Aminohexyl)maleimide trifluoroacetate salt Preparation Products And Raw materials |
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