2-Iminobiotin hydrobromide manufacturers
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| | 2-Iminobiotin hydrobromide Basic information |
| Product Name: | 2-Iminobiotin hydrobromide | | Synonyms: | GUANIDINOBIOTIN;HEXAHYDRO-2-IMINO-1H-THIENO[3,4-D]IMIDAZOLE-4-PENTANOIC ACID;5-((2S,3S,4R)-3,4-diaminotetrahydrothiophen-2-yl)pentanoic acid compound with sulfuric acid (1:1);5-((3aR,6S,6aS)-2-Amino-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazol-6-yl)pentanoic acid;Tetrahydro-2-iminothieno[3,4-d]imidazoline-4-valeric acid;2-Iminobiotine;2-IMINOBIOTIN 98+%;Guanidinobiotin, Hexahydro-2-imino-1H-thieno[3,4-d]imidazole-4-pentanoic acid | | CAS: | 13395-35-2 | | MF: | C10H17N3O2S | | MW: | 243.33 | | EINECS: | | | Product Categories: | | | Mol File: | 13395-35-2.mol |  |
| | 2-Iminobiotin hydrobromide Chemical Properties |
| Boiling point | 477.3±55.0 °C(Predicted) | | density | 1.60 | | storage temp. | 2-8°C | | solubility | 1 M HCl: 50 mg/mL, clear, colorless | | pka | 4.73±0.10(Predicted) | | form | White to off-white powder. | | color | White to off-white | | biological source | synthetic (organic) | | BRN | 18952 | | InChI | InChI=1S/C10H17N3O2S/c11-10-12-6-5-16-7(9(6)13-10)3-1-2-4-8(14)15/h6-7,9H,1-5H2,(H,14,15)(H3,11,12,13)/t6-,7-,9-/m0/s1 | | InChIKey | WWVANQJRLPIHNS-ZKWXMUAHSA-N | | SMILES | C1(N)=N[C@@]2([H])CS[C@@H](CCCCC(O)=O)[C@@]2([H])N1 |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | F | 10-21 | | Storage Class | 11 - Combustible Solids |
| | 2-Iminobiotin hydrobromide Usage And Synthesis |
| Uses | 2-Iminobiotin has been used as a competitive inhibitor to bind to biotic binding sites on streptavidin in order to restore fluorescence signal. | | General Description | 2-Iminobiotin is a cyclic guanidino analog of biotin that has high affinity for avidin at high pH (>9) and low affinity at low pH (<6). The proteins that are iminobiotinylated are selectively contained within the avidin column at pH 9 to 11 and may be eluted at pH 4 or by the addition of biotin. This technique may be very useful in the study of cell surface proteins by labeling and selectively recovering the components that are periodate-sensitive from intact human erythrocyte surface. 2-Iminobiotin reversibly inhibits NOS (nitric oxide synthases) via its guanidino group. It inhibits NO biosynthesis and may be important to understand the binding-site interactions for this important class of enzymes. NOS oxidizes the guanidino-nitrogen of L-arginine to produce nitric oxide and L-citrulline. | | IC 50 | iNOS |
| | 2-Iminobiotin hydrobromide Preparation Products And Raw materials |
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