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| | OX40/CD134 (C-Term) Rabbit Monoclonal Antibody (Clone RM313) Basic information |
| | OX40/CD134 (C-Term) Rabbit Monoclonal Antibody (Clone RM313) Chemical Properties |
| | OX40/CD134 (C-Term) Rabbit Monoclonal Antibody (Clone RM313) Usage And Synthesis |
| Description | OX40, also known as TNF receptor superfamily member 4 (TNFRSF4), is a type I transmembrane glycoprotein and the cognate receptor for the T cell co-stimulatory molecule OX40L (TNFSF4; Item No. 32065).1 OX40 assembles into trimers, with each monomer containing three cysteine-rich domains (CRDs) that bind OX40L and a cytoplasmic tail that interacts with TNF receptor-associated factor 1 (TRAF1), -2, -3, and -5 to induce a variety of intracellular signaling cascades, including NF-κB, ERK, PI3K, and Akt pathways.2,1 OX40 is transiently expressed on CD4+ and CD8+ T cells in response to antigen stimulation in humans and is localized to lipid rafts.3,1 Binding of an OX40 trimer to trimeric OX40L, expressed by antigen-presenting cells (APCs), including dendritic cells (DCs), macrophages, and B cells, forms a hexameric OX40-OX40L complex that promotes effector T cell phenotype and function, proliferation, survival, and memory.3 Increased OX40 levels have been found in inflamed tissues isolated from patients with a variety of autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus (SLE), or rheumatoid arthritis.3 Cayman's OX40 (C-Term) Rabbit Monoclonal Antibody (Clone RM313) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.WARNING This product is not for human or veterinary use. |
| | OX40/CD134 (C-Term) Rabbit Monoclonal Antibody (Clone RM313) Preparation Products And Raw materials |
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