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2-Iodoanisole

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CAS:529-28-2
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CAS:529-28-2
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Products Intro: Product Name:2-Iodoanisole
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2-Iodoanisole manufacturers

  • 2-Iodoanisole
  • 2-Iodoanisole pictures
  • $1.00
  • 2019-08-06
  • CAS:529-28-2
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 150KG
2-Iodoanisole Basic information
Product Name:2-Iodoanisole
Synonyms:1-Iodo-2-methoxybenzene, 2-Iodophenyl methyl ether;Adjacent iodine benzene Methyl ether;2-IODOANISOLE;O-IODOANISOLE;1-iodo-2-methoxy-benzen;Anisole, o-iodo-;Benzene, 1-iodo-2-methoxy-;Iodanisol
CAS:529-28-2
MF:C7H7IO
MW:234.03
EINECS:208-456-4
Product Categories:Building Blocks;C2 to C8;Chemical Synthesis;Ethers;Organic Building Blocks;Oxygen Compounds;Aromatic Ethers;Anisole;Anisoles, Alkyloxy Compounds & Phenylacetates;Iodine Compounds;alkyl Iodine
Mol File:529-28-2.mol
2-Iodoanisole Structure
2-Iodoanisole Chemical Properties
Melting point 588.5 °C
Boiling point 125-126 °C19 mm Hg(lit.)
density 1.799 g/mL at 25 °C(lit.)
refractive index n20/D 1.622(lit.)
Fp >110°C
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility alcohol: miscible(lit.)
form Liquid
color Clear yellow
Specific Gravity1.799
Water Solubility insoluble
Sensitive Light Sensitive
Merck 14,5028
BRN 1860243
InChI1S/C7H7IO/c1-9-7-5-3-2-4-6(7)8/h2-5H,1H3
InChIKeyDVQWNQBEUKXONL-UHFFFAOYSA-N
SMILESCOc1ccccc1I
CAS DataBase Reference529-28-2(CAS DataBase Reference)
NIST Chemistry Reference2-Iodoanisole(529-28-2)
EPA Substance Registry SystemBenzene, 1-iodo-2-methoxy- (529-28-2)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
8
TSCA TSCA listed
HS Code 29093090
Storage Class10 - Combustible liquids
MSDS Information
ProviderLanguage
2-Methoxyiodobenzene English
ACROS English
SigmaAldrich English
ALFA English
2-Iodoanisole Usage And Synthesis
Chemical PropertiesClear yellow liquid
Usessuzuki reaction
Uses2-Iodoanisole has been used in palladium/copper-catalyzed synthesis of o-(1-alkynyl)anisoles.
DefinitionChEBI: An organoiodine compound that is iodobenzene substituted by methoxy group at psotion 2.
General Description2-Iodoanisole participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.
Synthesis

(1) Prepare 2 moles of 20% NaI aqueous solution A and 2.1 moles of 8-10% sodium hypochlorite aqueous solution B for spare use;

(2) Add 900g of anisole in a 2L four-necked round-bottomed flask equipped with stirring, a temperature display, and two constant-pressure dropping funnels and heat it up to 60-70C with stirring; then, dropwise add the sodium iodide solution and sodium hypochlorite solution simultaneously at the ratio of molar ratio 1:1.05 with stirring;

(3) After dropping and adding, warm it up to 75-80C and get the light yellow reaction solution; cool it down to 75-80C; and cool it down to 80%. Sodium iodide solution and sodium hypochlorite solution;

(3) after dropping, warm up to 75~80 , stirring for 1 hour, to get light yellow reaction solution; cooled to room temperature, static phase splitting; the organic phase washed with water, drying and filtration, to get the anisole solution of 2-iodoanisole, distillation, cooling, curing, to get the white lumpy crystals, i.e., 2-iodoanisole, whose content is 98.5%, yield 93.4% .

Tag:2-Iodoanisole(529-28-2) Related Product Information
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