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| | 1-Bromo-3,4-dichlorobenzene Basic information |
| Product Name: | 1-Bromo-3,4-dichlorobenzene | | Synonyms: | 4-bromo-1,2-dichloro-benzen;Benzene, 1-bromo-3,4-dichloro-;Benzene,4-bromo-1,2-dichloro-;1-BROMO-3,4-DICHLOROBENZENE;3,4-Dichloro-1-bromobenzene;4-Bromo-1,2-dichlorobenzene, 98+%;3,4-Dichlorophenyl bromide;1,2-Dichloro-4-bromobenzene | | CAS: | 18282-59-2 | | MF: | C6H3BrCl2 | | MW: | 225.9 | | EINECS: | 242-160-6 | | Product Categories: | Aryl;Halogenated Hydrocarbons;Aromatic Halides (substituted);Benzene derivates;API intermediates;Bromine Compounds;Chlorine Compounds;bc0001;C6 | | Mol File: | 18282-59-2.mol |  |
| | 1-Bromo-3,4-dichlorobenzene Chemical Properties |
| Melting point | 24-25 °C(lit.) | | Boiling point | 124 °C33 mm Hg(lit.) | | density | 1.761 g/mL at 25 °C(lit.) | | vapor pressure | 0.6-25Pa at 20-50℃ | | refractive index | n20/D 1.599(lit.) | | Fp | 189 °F | | storage temp. | Sealed in dry,Room Temperature | | form | Liquid After Melting | | color | Clear slightly yellow | | Water Solubility | insoluble | | BRN | 1635735 | | InChI | 1S/C6H3BrCl2/c7-4-1-2-5(8)6(9)3-4/h1-3H | | InChIKey | CFPZDVAZISWERM-UHFFFAOYSA-N | | SMILES | Clc1ccc(Br)cc1Cl | | LogP | 4.3 at 25℃ and pH7 | | CAS DataBase Reference | 18282-59-2(CAS DataBase Reference) | | NIST Chemistry Reference | Benzene, 4-bromo-1,2-dichloro-(18282-59-2) | | EPA Substance Registry System | Benzene, 4-bromo-1,2-dichloro- (18282-59-2) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39-28A | | WGK Germany | 3 | | TSCA | TSCA listed | | HazardClass | IRRITANT | | HS Code | 29039990 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 1-Bromo-3,4-dichlorobenzene Usage And Synthesis |
| Chemical Properties | colorless to light yellow liqui | | Uses | 4-Bromo-1,2-dichlorobenzene participates in the synthesis of N-arylated sultams. | | General Description | 4-Bromo-1,2-dichlorobenzene participates in the synthesis of N-arylated sultams. | | Synthesis | General procedure for the synthesis of 4-bromo-1,2-dichlorobenzene from o-dichlorobenzene: 26.2 g of 1,2-dichlorobenzene was mixed with 2.75 g of iron powder, heated to 45 °C and 26 g of bromine was added slowly and dropwise at a rate of 0.2 mL/min. The reaction was completed after the dropwise addition process lasted for 2 hours. At the end of the reaction, the reaction was quenched by the addition of sodium sulfite solution and the reaction mixture was extracted with dichloromethane and the solvent was subsequently removed to give 41.6 g of crude product. Compositional analysis of the crude product showed the presence of 5.5% of 1,2-dichlorobenzene, 2.1% of 2,3-dichlorobromobenzene isomers and 0.6% of high-boiling substances (mainly dibrominated or polybrominated products). The unreacted 1,2-dichlorobenzene was recovered by distillation purification by first collecting the 100-110 °C fraction at pressures of -0.09 to -0.1 MPa, followed by collecting the 160-165 °C fraction at the same pressures to give 33.2 g of 4-bromo-1,2-dichlorobenzene with a purity of 98.5% and a molar yield of 90.3%. | | References | [1] Patent: CN107915659, 2018, A. Location in patent: Paragraph 0032-0034; 0037-0039; 0042-0044; 0047-0054
[2] Organic and Biomolecular Chemistry, 2003, vol. 1, # 14, p. 2506 - 2511 |
| | 1-Bromo-3,4-dichlorobenzene Preparation Products And Raw materials |
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