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| | 1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine Basic information |
| Product Name: | 1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine | | Synonyms: | 1,4,5,6-tetrahydro-1,2-dimethyl-pyrimidin;Pyrimidine,1,4,5,6-tetrahydro-1,2-dimethyl-;1,2-DIMETHYL-1,4,5,6-TETRAHYDROPYRIMIDINE;1,2-Dimethyl-1,4,5,6-Tetrahydropyrimidne;Two-1,4,5,6- four1,2-MethylhydrogenpyriMidine;1,2-Dimethyl-1,4,5,6-terahydropyrimidine;1,2-dimethyl-5,6-dihydro-4H-pyrimidine;1,2-Dimethyl-1,4,5,6 | | CAS: | 4271-96-9 | | MF: | C6H12N2 | | MW: | 112.17 | | EINECS: | 224-262-2 | | Product Categories: | Heterocyclic Compounds;Boron, Nitrile, Thio,& TM-Cpds | | Mol File: | 4271-96-9.mol |  |
| | 1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine Chemical Properties |
| Boiling point | 125°C (115 mmHg) | | density | 0,98 g/cm3 | | Fp | 73°C | | storage temp. | 2-8°C | | solubility | Acetone (Sparingly), Chloroform (Sparingly), DMSO (Sparingly), Methanol(Sparingly) | | form | Oil | | pka | 13.42±0.20(Predicted) | | Specific Gravity | 0.982 (20/4℃) | | color | Clear Colourless | | InChI | 1S/C6H12N2/c1-6-7-4-3-5-8(6)2/h3-5H2,1-2H3 | | InChIKey | ZFDWWDZLRKHULH-UHFFFAOYSA-N | | CAS DataBase Reference | 4271-96-9(CAS DataBase Reference) | | EPA Substance Registry System | Pyrimidine, 1,4,5,6-tetrahydro-1,2-dimethyl- (4271-96-9) |
| Hazard Codes | Xi | | Risk Statements | 22-34 | | Safety Statements | 23-26-36/37/39 | | RIDADR | 3267 | | WGK Germany | WGK 3 | | TSCA | TSCA listed | | HS Code | 2933599590 | | Storage Class | 11 - Combustible Solids |
| | 1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine Usage And Synthesis |
| Uses | 1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine is a reagent used in the synthesis of pyrantel derivatives with nematocidal activity. Also used as a reactant in the preparation of hapten antibodies that evoke terpenoid cyclization. | | Synthesis | General procedure for the synthesis of 1,2-dimethyl-1,4,5,6-tetrahydropyrimidine from N-[3-(methylamino)propyl]-acetamide: N-[3-(methylamino)propyl]-acetamide obtained from the previous step was dissolved in 200 mL of polyphosphoric acid ester (PPE) and placed in a microwave reactor. The reaction temperature was controlled to be 80 °C and the reaction time was 2 hours. After completion of the reaction, the reaction mixture was purified to afford the target product 1,2-dimethyl-1,4,5,6-tetrahydropyrimidine 240 g in 94.42% yield. | | References | [1] Patent: CN108822044, 2018, A. Location in patent: Paragraph 0025; 0028; 0031; 0032; 0037; 0042; 0047-0057 |
| | 1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine Preparation Products And Raw materials |
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