11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile

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11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:Usp22i-S02
CAS:309735-96-4
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:USP22-IN-1
CAS:309735-96-4
Purity:98.2% Package:1mg;40USD|5mg;94USD|10mg;146USD
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Tel: 021-61312847; 18021002903
Email: 3008007409@qq.com
Products Intro: Product Name:11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile
CAS:309735-96-4
Purity:98% Package:5mg Remarks:S89767
Company Name: Shanghai Chaolan Chemical Technology Center  
Tel: 021-QQ：65489617 15618227136
Email: Sales@ATKchemical.com
Products Intro: CAS:309735-96-4
Purity:98 Package:1G,5G,10G,50G,100G,500G
Company Name: DC Chemicals  
Tel: 021-58447131 13564518121
Email: doncunbiosci@gmail.com
Products Intro: Product Name:Usp22i-S02
Purity:98% HPLC Package:100mg,250mg,1g

11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile manufacturers

  • USP22-IN-1
  • USP22-IN-1 pictures
  • $40.00 / 1mg
  • 2026-04-20
  • CAS:309735-96-4
  • Min. Order:
  • Purity: 99.37%
  • Supply Ability: 10g
11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile Basic information
Product Name:11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile
Synonyms:11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile;Benzimidazo[1,2-b]isoquinoline-6-carbonitrile, 7,8,9,10-tetrahydro-11-(phenylamino)-;Usp22i-S02;USP22-IN-1;11-(Phenylamino)-7,8,9,10-tetrahydrobenzo[4,5]imidazo[1,2-b]isoquinoline-6-carbonitrile
CAS:309735-96-4
MF:C22H18N4
MW:338.41
EINECS:
Product Categories:
Mol File:309735-96-4.mol
11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile Structure
11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile Chemical Properties
density 1.29±0.1 g/cm3(Predicted)
storage temp. -10 to -25°C
solubility DMSO: 2mg/mL, clear
form powder
pka5.77±0.20(Predicted)
color white to beige
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile Usage And Synthesis
Biological ActivityCell-permeable and potent inhibitor of ubiquitin specific peptidase 22 (USP22) th at exhibits anticancer activity.


Usp22i-S02 is a cell-permeable benzimidazoisoquinoline-carbonitrile analog th at is shown to reversibly occupy USP22 (ubiquitin specific peptidase 22) catalytic domain and suppress its functions. Usp22i-S02 arrests Usp22-mediated Foxp3 deubiquitination in iTREG cells in a time and dose-dependent manner. Usp22i-S02 administration enhances antitumor immunity with low toxicity in LLC1-challenged mice (20 mg/kg) and reduces tumor burden in a Treg-specific manner. immunity with low toxicity in LLC1-challenged mice (20 mg/kg) and reduces tumor burden in a Treg-specific manner.
11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile Preparation Products And Raw materials
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