| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:α-Glucosidase-IN-21
CAS:321686-01-5
Package:25mg/RMB 10600;100mg/RMB 17500;50mg/RMB 13800
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| Company Name: |
Specs
|
| Tel: |
+31 15 251 8111 |
| Email: |
info@specs.net |
| Products Intro: |
|
2-(3,4-dimethoxyphenyl)-4-(4-methylphenyl)-2,3-dihydro-1,5-benzothiazepine manufacturers
- α-Glucosidase-IN-21
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- $1520.00 / 25mg
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2026-01-05
- CAS:321686-01-5
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | 2-(3,4-dimethoxyphenyl)-4-(4-methylphenyl)-2,3-dihydro-1,5-benzothiazepine Basic information |
| | 2-(3,4-dimethoxyphenyl)-4-(4-methylphenyl)-2,3-dihydro-1,5-benzothiazepine Chemical Properties |
| | 2-(3,4-dimethoxyphenyl)-4-(4-methylphenyl)-2,3-dihydro-1,5-benzothiazepine Usage And Synthesis |
| Uses | α-Glucosidase-IN-21 (Compound 2B) is a potent, orally active α-glucosidase inhibitor with an IC50 of 2.62 μM. α-Glucosidase-IN-21 shows anti-diabetic activity[1]. | | in vivo | α-Glucosidase-IN-21 (Compound 2B; 10 and 20 mg/kg; p.o.; daily, for 4 weeks) has anti-diabetic activity in Streptozocin (HY-13753)-induced diabetic rats[1].
α-Glucosidase-IN-21 (10 and 20 mg/kg; p.o.; once) significantly decreases the serum glucose level after the administration of glucose (3 g/kg, oral) in rats[1].
α-Glucosidase-IN-21 (2000 mg/kg; p.o.; daily, for 2 weeks) demonstrates no mortality in mice[1]. | Animal Model: | Male Wistar albino rats (170-200 g), Streptozotocin-induced diabetes model[1] | | Dosage: | 10 and 20 mg/kg | | Administration: | Oral administration; daily, for 4 weeks | | Result: | Decreased the level of blood glucose, reversed Streptozocin-induced body weight loss. Showed antihyperlipidemic effects on Streptozotocin-induced diabetes, reduced to a significant level of serum biomarkers. |
| | References | [1] Mehmood R, et al. Synthesis of Novel 2, 3-Dihydro-1, 5-Benzothiazepines as α-Glucosidase Inhibitors: In Vitro, In Vivo, Kinetic, SAR, Molecular Docking, and QSAR Studies. ACS Omega, 2022 Aug 17. |
| | 2-(3,4-dimethoxyphenyl)-4-(4-methylphenyl)-2,3-dihydro-1,5-benzothiazepine Preparation Products And Raw materials |
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