|
|
| | 2,6-Dichloronicotinamide Basic information |
| Product Name: | 2,6-Dichloronicotinamide | | Synonyms: | 2,6-Dichloronicotinamide;2,6-Dichloropyridine-3-carboxamide;DichloronicotinaMide;2,6-Dichloronicotimide;2,6-Dichloropyridine-3-carboxamide 97%;3-Pyridinecarboxamide, 2,6-dichloro-;2,6-Dichloronicotinamide ISO 9001：2015 REACH;Nicotinamide Impurity 99 | | CAS: | 62068-78-4 | | MF: | C6H4Cl2N2O | | MW: | 191.01 | | EINECS: | | | Product Categories: | | | Mol File: | 62068-78-4.mol |  |
| | 2,6-Dichloronicotinamide Chemical Properties |
| Melting point | 148-151 °C | | Boiling point | 315.5±42.0 °C(Predicted) | | density | 1.524±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | form | powder | | pka | 13.91±0.50(Predicted) | | Appearance | White to off-white Solid |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38 | | Safety Statements | 26 | | WGK Germany | 3 | | HS Code | 2933399990 |
| | 2,6-Dichloronicotinamide Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 2,6-dichloronicotinamide from 2,6-dichloronicotinonitrile: To 2,6-dichloronicotinonitrile (1.73 g, 10 mmol) was added concentrated sulfuric acid (10 mL) and water (2 mL). The reaction mixture was heated to 90 °C and stirred continuously for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently slowly poured into ice water. The pH of the mixture was adjusted with ammonia to 8. The precipitate precipitated was collected by filtration, washed with cold water (20 mL) and finally dried under vacuum to give 2,6-dichloronicotinamide as a brown solid (1.4 g, 73% yield). Mass spectrum (ESI): m/z = 191.1 [M + H]+. | | References | [1] Patent: WO2015/48662, 2015, A2. Location in patent: Page/Page column 37
[2] Patent: CN107226805, 2017, A. Location in patent: Paragraph 0097; 0098; 0099; 0100; 0101 |
| | 2,6-Dichloronicotinamide Preparation Products And Raw materials |
|