- Z-PRO-NH2
-
- $1.00
-
2024-08-05
- CAS:34079-31-7
- Min. Order: 1Kg
- Purity: 98%
- Supply Ability: 20T
- Z-PRO-NH2
-
-
2023-10-22
- CAS:34079-31-7
- Min. Order: 1drums
- Purity: 99%min.
- Supply Ability: 10tons
- Z-PRO-NH2
-
- $100.00
-
2019-07-06
- CAS:34079-31-7
- Min. Order: 1KG
- Purity: 99
|
| | Z-PRO-NH2 Basic information |
| | Z-PRO-NH2 Chemical Properties |
| Melting point | 90-95℃ | | Boiling point | 465.6±44.0 °C(Predicted) | | density | 1.263±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | soluble in Methanol | | pka | 15.95±0.20(Predicted) | | form | Solid | | color | White to Almost white | | Major Application | peptide synthesis | | InChI | InChI=1S/C13H16N2O3/c14-12(16)11-7-4-8-15(11)13(17)18-9-10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9H2,(H2,14,16)/t11-/m0/s1 | | InChIKey | ZCGHEBMEQXMRQL-NSHDSACASA-N | | SMILES | N1(C(OCC2=CC=CC=C2)=O)CCC[C@H]1C(N)=O | | CAS DataBase Reference | 34079-31-7(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38 | | Safety Statements | 36 | | WGK Germany | 3 | | HS Code | 29339900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | Z-PRO-NH2 Usage And Synthesis |
| Chemical Properties | White crystals | | Uses | peptide synthesis | | reaction suitability | reaction type: solution phase peptide synthesis | | Synthesis | General procedure for the synthesis of (S)-1-N-benzyloxycarbonylproline from N-benzyloxycarbonyl-L-proline: 1-{[(phenylmethyl)oxy]carbonyl}-L-proline (8.0 g, 32.09 mmol) was solubilized in 1,4-dioxane (40 mL), and pyridine (1.5 mL) and di-tert-butyl dicarbonate ((Boc)2O, 9.1 g 41.72 mmol). Ammonium bicarbonate (3.2 g, 40.43 mmol) was then added. The reaction mixture was stirred at room temperature overnight and then diluted with ethyl acetate (100 mL) and washed sequentially with water (50 mL) and 5% sulfuric acid (H2SO4). The organic layer was separated, dried over anhydrous sodium sulfate (Na2SO4) and filtered. The solvent was removed by distillation under reduced pressure to give a clarified oil. The oily material was ground with ether, the precipitate was collected by filtration and dried under vacuum to afford (S)-1-N-Benzyloxycarbonylprolinamide as a white solid (3.9 g, 49% yield). The mass spectrum showed [M+H]+ of 249. | | References | [1] Organic and Biomolecular Chemistry, 2005, vol. 3, # 1, p. 84 - 96
[2] Synlett, 2004, # 3, p. 558 - 560
[3] Patent: WO2005/121135, 2005, A1. Location in patent: Page/Page column 240-241
[4] Canadian Journal of Chemistry, 2007, vol. 85, # 2, p. 85 - 95
[5] Journal of the American Chemical Society, 2018, vol. 140, # 5, p. 1627 - 1631 |
| | Z-PRO-NH2 Preparation Products And Raw materials |
|