|
|
| | 5-fluoropyrimidin-4-amine Basic information |
| Product Name: | 5-fluoropyrimidin-4-amine | | Synonyms: | 5-fluoropyrimidin-4-amine;5-Fluoro-pyrimidin-4-ylamine;4-Pyrimidinamine, 5-fluoro-;5-fluoropyrimidin-4-amine analogue;5-fluoropyrimidin-4-amine ISO 9001：2015 REACH;4-Amino-5-fluoropyrimidine | | CAS: | 811450-26-7 | | MF: | C4H4FN3 | | MW: | 113.09 | | EINECS: | | | Product Categories: | | | Mol File: | 811450-26-7.mol |  |
| | 5-fluoropyrimidin-4-amine Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | form | claggy crystalline powder | | color | White |
| Safety Statements | 24/25 | | HS Code | 29335990 |
| | 5-fluoropyrimidin-4-amine Usage And Synthesis |
| Synthesis | General procedure: pre-step A Synthesis of 5-fluoro-4-pyrimidinamine
A mixture of 4-chloro-5-fluoropyrimidine (200 mg, 1.509 mmol) and ammonia (3.3 mL, 45.3 mmol) in methanol (580 μL) was placed in a microwave reactor, heated to 110 °C, and reacted for 30 min. Upon completion of the reaction, the reaction mixture was filtered and the solid product was collected and dried to give 5-fluoropyrimidin-4-amine (100 mg, 0.875 mmol, 58% yield) as a white solid. Mass spectrum (electrospray positive ion mode) m/z 114.1 ([M+H]+). | | References | [1] Patent: US2013/345120, 2013, A1. Location in patent: Page/Page column
[2] Patent: US8901119, 2014, B2. Location in patent: Page/Page column |
| | 5-fluoropyrimidin-4-amine Preparation Products And Raw materials |
|