- DB11
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- $1.50
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2026-05-15
- CAS:981-34-0
- Min. Order: 1g
- Purity: 99.0% Min
- Supply Ability: 100 Tons
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| | 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Basic information |
| Product Name: | 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione | | Synonyms: | (9β)-9,11β-Epoxy-16β-methyl-17,21-dihydroxypregna-1,4-diene-3,20-dione;9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione;Einecs 213-563-4;Betamethasone 9,11-Epoxide;(9β,11β,16β)-;9beta,11beta-Epoxy-1;DB11(16B-Methyl Epoide);DB11(16β-Methyl Epoide) | | CAS: | 981-34-0 | | MF: | C22H28O5 | | MW: | 372.45 | | EINECS: | 213-563-4 | | Product Categories: | Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Steroids;981-34-0 | | Mol File: | 981-34-0.mol |  |
| | 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Chemical Properties |
| Melting point | 210-220 ºC | | Boiling point | 564.9±50.0 °C(Predicted) | | density | 1.32±0.1 g/cm3(Predicted) | | vapor pressure | 0-357.304Pa at 25℃ | | storage temp. | Refrigerator | | solubility | Chloroform (Slightly, Heated), Dioxane (Slightly, Heated), DMSO (Slightly, Heated) | | form | Solid | | pka | 12.56±0.70(Predicted) | | color | White to Light Beige | | Major Application | pharmaceutical small molecule | | InChIKey | GBDXNHBVYAMODG-OBDZOPJXNA-N | | SMILES | C[C@]12C=CC(=O)C=C1CC[C@@]1([H])[C@]3([H])C[C@H](C)[C@](O)(C(=O)CO)[C@@]3(C)C[C@@H]3O[C@]213 |&1:1,10,12,15,17,23,26,28,r| |
| | 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Usage And Synthesis |
| Description | 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione (Betamethasone EP Impurity E) is a metabolite of Mometasone Furoate (M490000) which is a tropical corticosteroid used as an anti-inflammatory. Low solubility in most solvent. 9,11β-epoxysteroid compounds can be prepared by 9-position fluorination to obtain dexamethasone. By modifying its 3-bit, 6-bit, 16-bit, and 21-bit, a series of drugs can be prepared. | | Chemical Properties | Off-White Solid | | Uses | 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione is a metabolite of Mometasone furoate. It has low solubility in most solvents. | | Preparation | Add sodium sulfite and sodium hydroxide to water, stir to dissolve, and then add methanol. The raw material was added for hydrolysis reaction. After the reaction for 3h, glacial acetic acid was added to adjust the pH=6~8. The water was added to the solution and crystallize at 0 ℃. Finally, 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione was obtained after purification.
 | | Toxics Screening Level | The initial threshold screening level (ITSL) for betamethasone 11 is 17 μg/m3 based on an annual averaging time. |
| | 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Preparation Products And Raw materials |
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