740 Y-P manufacturers
- 740 Y-P
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- $89.00
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2026-06-11
- CAS:1236188-16-1
- Purity: 99.71%
- Supply Ability: 10g
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| | 740 Y-P Basic information |
| Product Name: | 740 Y-P | | Synonyms: | 740 Y-P;RQIKIWFQNRRMKWKKSDGGYMDMS (Modifications: Tyr-21 = pTyr);PDGFR 740Y-P;740 Y-P, >96%;740 Y-P,740YPDGFR,PDGFR 740Y-P, >96%;740YPDGFR;L-Serine, L-arginyl-L-glutaminyl-L-isoleucyl-L-lysyl-L-isoleucyl-L-tryptophyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-L-arginyl-L-arginyl-L-methionyl-L-lysyl-L-tryptophyl-L-lysyl-L-lysyl-L-seryl-L-α-aspartylglycylglycyl-O-phosphono-L-tyrosyl-L-methionyl-L-α-aspartyl-L-methionyl-;740 Y-P (PDGFR 740Y-P) | | CAS: | 1236188-16-1 | | MF: | C141H222N43O39PS3 | | MW: | 3270.7 | | EINECS: | | | Product Categories: | Protein Kinase | | Mol File: | 1236188-16-1.mol |  |
| | 740 Y-P Chemical Properties |
| density | 1.51±0.1 g/cm3(Predicted) | | storage temp. | -20°C, protect from light | | solubility | ≥163.54 mg/mL in DMSO; insoluble in EtOH; ≥4.87 mg/mL in H2O | | form | solid | | color | White to off-white | | Water Solubility | Soluble to 1 mg/ml in water | | Sequence | Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Ser-Asp-Gly-Gly-{Tyr(PO2)}-Met-Asp-Met-Ser | | InChIKey | XCGMILZGRGEWHL-QYGSNONCSA-N |
| Storage Class | 11 - Combustible Solids |
| | 740 Y-P Usage And Synthesis |
| Uses | 740 Y-P (740YPDGFR; PDGFR 740Y-P) is a potent and cell-permeable PI3K activator. 740 Y-P readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone[1]. | | in vivo | 740 Y-P is not only internalised in living cells but can also interact with p85 in vivo[1].740 Y-P (intraperitonealinjection; 10 mg/kg; 6 weeks) decreases the degree of ROS levels in Aβ(25-32) treated hippocampal tissues and increases the extent of AKT and PI3K phosphorylation in alzheimer’s disease (AD) rat model[3]. | | IC 50 | PI3K | | storage | Store at -20°C | | References | [1] Derossi D, et al. Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. DOI:10.1006/bbrc.1998.9444
[2] Xiaoli Feng, et al. Graphene Oxide Induces p62/SQSTM-dependent Apoptosis Through the Impairment of Autophagic Flux and Lysosomal Dysfunction in PC12 Cells. Acta Biomater.2018 Nov;81:278-292. DOI:10.1016/j.actbio.2018.09.057
[3] Zhiqing Sun, et al. GABAB Receptor-Mediated PI3K/Akt Signaling Pathway Alleviates Oxidative Stress and Neuronal Cell Injury in a Rat Model of Alzheimer's Disease. J Alzheimers Dis.2020;76(4):1513-1526. DOI:10.3233/JAD-191032 |
| | 740 Y-P Preparation Products And Raw materials |
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