硫酸奥西那林
| 中文名称 | 硫酸奥西那林 |
|---|---|
| 中文同义词 | 3,5-二羟基-alpha-((异丙基氨基)甲基)-苄醇硫酸盐;硫酸奥西那林;异丙喘宁硫酸盐溶液,100PPM;硫酸奥西那林(异丙喘宁);异丙喘宁硫酸盐;奥西那林半硫酸盐 标准品;奥西那林半硫酸盐;硫酸异丙喘宁 |
| 英文名称 | Orciprenaline sulfate |
| 英文同义词 | 1-(3,5-dihydroxyphenyl)-1-hydroxy-2-isopropylaminoethanesulfate;1-(3,5-dihydroxyphenyl)-2-(isopropylamino)ethanolsulfate;3,5-dihydroxy-alpha-((isopropylamino)methyl)benzylalcoholsulfate;3,5-dihydroxy-alpha-((isopropylamino)methyl)-benzylalcohosulfate(2:1)(s;3-benzenediol,5-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-sulfate(2:1);alotec;metaprel;novasmasol |
| CAS号 | 5874-97-5 |
| 分子式 | C22H36N2O10S |
| 分子量 | 520.59 |
| EINECS号 | 227-539-6 |
| 相关类别 | 医药原料药;瘦肉精类;小分子抑制剂;医药原料;有机化工原料;Adrenergics;Agonists;Neurotransmitters;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;5874-97-5 |
| Mol文件 | 5874-97-5.mol |
| 结构式 |  |
硫酸奥西那林 性质
| 熔点 | 202-203° |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 易溶于水，微溶于乙醇（96%），几乎不溶于二氯甲烷。 |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| 稳定性 | 吸湿性 |
| 主要应用 | pharmaceutical (small molecule) |
| InChI | 1S/2C11H17NO3.H2O4S/c2*1-7(2)12-6-11(15)8-3-9(13)5-10(14)4-8;1-5(2,3)4/h2*3-5,7,11-15H,6H2,1-2H3;(H2,1,2,3,4) |
| InChIKey | MKFFGUZYVNDHIH-UHFFFAOYSA-N |
| SMILES | OS(O)(=O)=O.CC(C)NCC(O)c1cc(O)cc(O)c1.CC(C)NCC(O)c2cc(O)cc(O)c2 |
IC50: 68 nM (β2-adrenergic receptor)
Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment enhances β-arrestin2 and its interaction with IκBα in high glucose-induced THP-1 cells and bone marrow macrophages.
Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment leads to downregulation of NF-κB in high glucose-induced THP-1 cells and bone marrow macrophages.
Western Blot Analysis
| Cell Line: | THP-1 cells and bone marrow macrophages |
| Concentration: | 10 μM |
| Incubation Time: | 74 hours |
| Result: | Enhanced β-arrestin2 and its interaction with IκBα. |
RT-PCR
| Cell Line: | THP-1 cells and bone marrow macrophages |
| Concentration: | 10 μM |
| Incubation Time: | 74 hours |
| Result: | Led to downregulation of NF-κB. |
Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications.
安全信息
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英文
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