CALMIDAZOLIUM CHLORIDE

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Company Name: Sigma-Aldrich  
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CALMIDAZOLIUM CHLORIDE Basic information
Product Name:CALMIDAZOLIUM CHLORIDE
Synonyms:COMPOUND 48/80;COMPOUND 48/80 TRIHYDROCHLORIDE;COMPOUND R24571;R 24571;R 24571 CHLORIDE;CALMODULIN INHIBITOR R 24571;CALMIDAZOLIUM;CALMIDAZOLIUM CHLORIDE
CAS:94724-12-6
MF:C32H45N3O3
MW:519.72
EINECS:
Product Categories:Antibiotics A-FEnzyme Inhibitors by Enzyme;Phospholipase CLipids in Cell Signaling;Phospholipase Inhibitors;Antibiotics;Antibiotics A to;P to;Phospholipid Metabolism
Mol File:94724-12-6.mol
CALMIDAZOLIUM CHLORIDE Structure
CALMIDAZOLIUM CHLORIDE Chemical Properties
Boiling point 630.9±50.0 °C(Predicted)
density 1.050±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility H2O: 50 mg/mL
pka10.81±0.10(Predicted)
form solid
color white
Safety Information
Hazard Codes T
Risk Statements 23/24/25
Safety Statements 22-24/25-45-36/37
RIDADR UN 2811 6.1/PG 2
WGK Germany 3
F 3-8-10
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
CALMIDAZOLIUM CHLORIDE Usage And Synthesis
UsesCompound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a "selective" mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways[1][2].
References[1] Schemann M, et al. The mast cell degranulator compound 48/80 directly activates neurons. PLoS One. 2012;7(12):e52104. DOI:10.1371/journal.pone.0052104
[2] Wang YH, Taché Y, Harris AG, Kreutner W, Daly AF, Wei JY. Desloratadine prevents compound 48/80-induced mast cell degranulation: visualization using a vital fluorescent dye technique. Allergy. 2005;60(1):117-124. DOI:10.1111/j.1398-9995.2004.00641.x
[3] Darzynkiewicz Z, Carter S. Compound 48/80 impairs cytokinesis in murine leukemic cells. J Cell Physiol. 1984;119(1):1-6. DOI:10.1002/jcp.1041190102
CALMIDAZOLIUM CHLORIDE Preparation Products And Raw materials
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