| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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orderCN@merckgroup.com |
| Products Intro: |
Product Name:Compound 48/80
CAS:94724-12-6
Purity:Compound 48/80 Package:250MG Remarks:C2313-250MG
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| | CALMIDAZOLIUM CHLORIDE Basic information |
| | CALMIDAZOLIUM CHLORIDE Chemical Properties |
| Boiling point | 630.9±50.0 °C(Predicted) | | density | 1.050±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | H2O: 50 mg/mL | | form | solid | | pka | 10.81±0.10(Predicted) | | color | white |
| | CALMIDAZOLIUM CHLORIDE Usage And Synthesis |
| Uses | Compound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a "selective" mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways[1][2]. | | References | [1] Schemann M, et al. The mast cell degranulator compound 48/80 directly activates neurons. PLoS One. 2012;7(12):e52104. DOI:10.1371/journal.pone.0052104
[2] Wang YH, Taché Y, Harris AG, Kreutner W, Daly AF, Wei JY. Desloratadine prevents compound 48/80-induced mast cell degranulation: visualization using a vital fluorescent dye technique. Allergy. 2005;60(1):117-124. DOI:10.1111/j.1398-9995.2004.00641.x
[3] Darzynkiewicz Z, Carter S. Compound 48/80 impairs cytokinesis in murine leukemic cells. J Cell Physiol. 1984;119(1):1-6. DOI:10.1002/jcp.1041190102 |
| | CALMIDAZOLIUM CHLORIDE Preparation Products And Raw materials |
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