2-(3-Aminophenyl)acetic acid ethyl ester manufacturers
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| | 2-(3-Aminophenyl)acetic acid ethyl ester Basic information |
| Product Name: | 2-(3-Aminophenyl)acetic acid ethyl ester | | Synonyms: | (3-Aminophenyl)acetic acid ethyl ester;2-(3-Aminophenyl)acetic acid ethyl ester;Ethyl 3-aminophenylacetate;Ethyl 2-(3-aminophenyl)acetate;3-Amino-benzeneacetic acid ethyl ester;Benzeneacetic acid, 3-amino-, ethyl ester | | CAS: | 52273-79-7 | | MF: | C10H13NO2 | | MW: | 179.22 | | EINECS: | | | Product Categories: | | | Mol File: | 52273-79-7.mol |  |
| | 2-(3-Aminophenyl)acetic acid ethyl ester Chemical Properties |
| Boiling point | 138-140 °C(Press: 3-4 Torr) | | density | 1.112±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 4.36±0.10(Predicted) | | Appearance | Brown to black Liquid |
| | 2-(3-Aminophenyl)acetic acid ethyl ester Usage And Synthesis |
| Synthesis | General procedure for the synthesis of ethyl 2-(3-aminophenyl)acetate from ethyl 3-nitrophenylacetate: ethyl 2-(3-nitrophenyl)acetate (3h) (1.05 g, 3.40 mmol) was dissolved in methanol (25 mL) and hydrogenation reaction was carried out for 4 h by adding 10% Pd/C (catalytic amount) as a catalyst. After completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford the target product ethyl 2-(3-aminophenyl)acetate (4h). The product was characterized by 1H-NMR (200 MHz, CDCl3): δ 1.25 (t, 3H, J = 7.2 Hz), 3.51 (s, 2H), 4.14 (q, 2H, J = 7.2 Hz), 6.59-6.71 (m, 3H), 7.11 (t, 1H, J = 7.8 Hz). The reaction was carried out quantitatively in 100% yield. | | References | [1] Patent: EP3381898, 2018, A1. Location in patent: Paragraph 0200; 0265
[2] Collection of Czechoslovak Chemical Communications, 1995, vol. 60, # 4, p. 659 - 669
[3] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 3, p. 1206 - 1217
[4] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 1, p. 217 - 220
[5] Patent: US6150373, 2000, A |
| | 2-(3-Aminophenyl)acetic acid ethyl ester Preparation Products And Raw materials |
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