2-Amino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one

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2-Amino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one Basic information
Product Name:2-Amino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one
Synonyms:2-amino-6,7-dihydro-5H-[1,3]thiazolo[5,4-c]pyridin-4-one;Thiazolo[5,4-c]pyridin-4(5H)-one, 2-amino-6,7-dihydro-;2-Amino-5,6,7,7a-tetrahydro-3aH-thiazolo[5,4-c]pyridin-4-one;2-amino-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-4-one;2-Amino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one
CAS:26493-11-8
MF:C6H7N3OS
MW:169.2
EINECS:
Product Categories:
Mol File:26493-11-8.mol
2-Amino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one Structure
2-Amino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one Chemical Properties
Boiling point 559.4±39.0 °C(Predicted)
density 1.487±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka13.47±0.20(Predicted)
AppearanceWhite to off-white Solid
Safety Information
MSDS Information
2-Amino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one Usage And Synthesis
Synthesis
2-AMino-4-oxo-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylic acid tert-butyl ester

1312412-88-6

2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE

26493-11-8

Step i: Deprotection reaction of tert-butyl 2-amino-4-oxo-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate To a 50 mL round bottom flask was added tert-butyl 2-amino-4-oxo-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate (0.7 g, 0.0026 mol) and 1,4-dioxane (10 mL). Subsequently, a 1,4-dioxane solution of 4 M hydrochloric acid (10 mL) was added to the same flask. The reaction mixture was stirred at room temperature for 3 hours. After completion of the reaction, the volatile solvent was removed by distillation under reduced pressure to give the crude product. The solid was washed with ether to afford purified 2-amino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one (0.4 g, 96% yield).LC-MS analysis showed the molecular ion peak of the target compound as 169.9 [M + H]+.

References[1] Patent: WO2015/101928, 2015, A1. Location in patent: Page/Page column 66; 67
[2] Patent: WO2011/73339, 2011, A1. Location in patent: Page/Page column 42
2-Amino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one Preparation Products And Raw materials
Raw materials2-AMino-4-oxo-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylic acid tert-butyl ester-->1,4-Dioxane-->Hydrochloric acid
Tag:2-Amino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one(26493-11-8) Related Product Information
2-Amino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one hydrochloride 2-AMino-4-oxo-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylic acid tert-butyl ester 2-Bromo-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one 2-Bromo-7-methyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one 2-Bromo-7-oxo-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylic acid tert-butyl ester Thiazolo[5,4-c]pyridine-5(4H)-carboxylic acid, 2-bromo-6,7-dihydro-4-oxo-, 1,1-dimethylethyl ester