- 2-Chlorophenylboronic acid
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- $34.00 / 1kg
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2025-09-25
- CAS:3900-89-8
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
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| | 2-Chlorophenylboronic acid Basic information |
| | 2-Chlorophenylboronic acid Chemical Properties |
| Melting point | 92-102 °C (lit.) | | Boiling point | 306.3±44.0 °C(Predicted) | | density | 1.32±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Soluble in DMSO, Methanol. | | form | Crystalline Powder | | pka | 8.23±0.58(Predicted) | | color | White | | BRN | 3030414 | | InChI | InChI=1S/C6H6BClO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4,9-10H | | InChIKey | RRCMGJCFMJBHQC-UHFFFAOYSA-N | | SMILES | B(C1=CC=CC=C1Cl)(O)O | | CAS DataBase Reference | 3900-89-8(CAS DataBase Reference) |
| Hazard Codes | Xn,Xi | | Risk Statements | 36/37/38-22 | | Safety Statements | 37/39-26-36 | | WGK Germany | 3 | | TSCA | No | | HazardClass | IRRITANT | | HS Code | 29319090 | | Storage Class | 11 - Combustible Solids |
| | 2-Chlorophenylboronic acid Usage And Synthesis |
| Chemical Properties | white crystalline powder | | Uses | suzuki reaction | | Uses | 2-Chlorophenylboronic Acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity. | | Synthesis | Step (f): n-BuLi (2.5 M, n-hexane solution, 2.5 mL, 1.2 eq., 6.3 mmol) was slowly added dropwise under nitrogen protection to a solvent mixture of toluene and THF (4: 1, 10 mL, 10 mL) containing 2-bromo chlorobenzene (I) (1 g, 0.6 mL, 5.2 mmol) and triisopropyl borate (1.44 mL, 1.2 eq., 6.27 mmol). 1, 10 mL) in a reaction temperature of -70°C and a dropwise addition time of 1 hour. After the dropwise addition, the reaction mixture was continued to be stirred at -70°C for 0.5 hr. Subsequently, the reaction system was slowly warmed to -20 °C and the reaction was quenched by the addition of 2N HCl solution (5 mL). After the reaction mixture was brought to room temperature, it was extracted with dichloromethane. The organic phases were combined, dried and concentrated to give a white solid. The solid was purified by recrystallization from acetonitrile to give the target product 2-chlorophenylboronic acid in 98% yield (800 mg). | | References | [1] Patent: WO2013/90725, 2013, A1. Location in patent: Page/Page column 68
[2] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 590 - 603
[3] Journal of Organic Chemistry, 2002, vol. 67, # 15, p. 5394 - 5397 |
| | 2-Chlorophenylboronic acid Preparation Products And Raw materials |
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