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| | 7-Chloro-[1,8]naphthyridin-2-ol Basic information |
| | 7-Chloro-[1,8]naphthyridin-2-ol Chemical Properties |
| Melting point | 255-257℃ | | Boiling point | 379.4±44.0 °C(Predicted) | | density | 1.50 | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 1.74±0.40(Predicted) | | Appearance | Brown to reddish brown Solid |
| | 7-Chloro-[1,8]naphthyridin-2-ol Usage And Synthesis |
| Synthesis | Tert-butyl 3-[6-chloro-2-(2,2-dimethylpropanamido)pyridin-3-yl]-3-hydroxypropanoate (4 g, 11 mmol) was used as a raw material, which was dissolved in a mixed solution of 1 M HCl/dioxane (1:1, 50 mL) and reacted overnight. After completion of the reaction, ice water was added to the mixture and the precipitated solid was collected by filtration and dried to afford 7-chloro-1,8-diazanaphthalen-2-ol (1.7 g, 9.4 mmol, 86% yield). The obtained product could be used in the subsequent reaction without further purification.LC-MS analysis showed the (M-H)-peak was 181.1. | | References | [1] Journal of Organic Chemistry, 1990, vol. 55, # 15, p. 4744 - 4750
[2] Patent: WO2017/211759, 2017, A1. Location in patent: Page/Page column 94 |
| | 7-Chloro-[1,8]naphthyridin-2-ol Preparation Products And Raw materials |
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