松茋
| 中文名称 | 松茋 |
|---|---|
| 中文同义词 | (E)-3-[2-(4-羟基苯基)乙烯基]-5-甲氧基苯酚;5-甲氧基-3,4'-二羟基茋;松;松芪;3-[(1E)-2-(4-羟基苯基)乙烯基]-5-甲氧基苯酚;松茋;反式-松茋;白藜芦醇-3-甲醚 |
| 英文名称 | Pinostilbene |
| 英文同义词 | Pinostilbene;Pistilbene;3,4'-Dihydroxy-5-methoxy-trans-stilbene;3-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-5-methoxyphenol;trans-Pinostilbene;Pinostilbene hydrate;trans-Pinostilbene hydrate;3-methoxy-4',5-dihydroxy-trans-stilbene |
| CAS号 | 42438-89-1 |
| 分子式 | C15H14O3 |
| 分子量 | 242.27 |
| EINECS号 | 694-822-2 |
| 相关类别 | 试剂;植物提取物;芳烃;分析试剂标准品;中药对照品;其它酚类;标准品 -中药标准品;有机原料 |
| Mol文件 | 42438-89-1.mol |
| 结构式 |  |
松茋 性质
| 熔点 | 117-118℃ |
|---|---|
| 密度 | 1.252 |
| 储存条件 | Keep in dark place,Inert atmosphere,2-8°C |
| 溶解度 | 在DMSO中的溶解度≥13mg/mL |
| 形态 | 粉末 |
| 颜色 | 白色至棕褐色 |
| InChI | InChI=1S/C15H14O3/c1-18-15-9-12(8-14(17)10-15)3-2-11-4-6-13(16)7-5-11/h2-10,16-17H,1H3/b3-2+ |
| InChIKey | KUWZXOMQXYWKBS-NSCUHMNNSA-N |
| SMILES | C1(O)=CC(OC)=CC(/C=C/C2=CC=C(O)C=C2)=C1 |
Pinostilbene (0- 40 μM; 24 hours, 48 hours) does not cause significant inhibition on the growth of normal colon cells.
Pinostilbene (20 μM, 40 μM; 24 hours, 48 hours) causes a significant and dose-dependent increase in the percentage of cells in S phase in both HCT116 and HT29 cells compared to the control cells.
Pinostilbene at μM also induces a modest increase of cell population in G2/M phase in HT29 cells.
Pinostilbene(20 μM, 40 μM; 24 hours, 48 hours) modulates expression of key signaling proteins related to cell proliferation and apoptosis.
Pinostilbene also acts as a resveratrol methylated derivative and displays protective effects against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells.
Cell Viability Assay
| Cell Line: | HCT116 cells, HT29 cells |
| Concentration: | 24 hours, 48 hours |
| Incubation Time: | 0-100 μM |
| Result: | Inhibited the growth of two human colon cancer cells. |
Apoptosis Analysis
| Cell Line: | HCT116 cells, HT29 cells |
| Concentration: | 20 μM, 40 μM |
| Incubation Time: | 24 hours, 48 hours |
| Result: | Caused a significant and dose-dependent increase in the percentage of cells in S phase. |
Cell Viability Assay
| Cell Line: | HCT116 cells |
| Concentration: | 20 μM,40 μM |
| Incubation Time: | 24 hours, 48 hours |
| Result: | Significantly increased the expression levels of p53, Bax, cleaved caspase-3, cleaved PARP and p21 Cip1/Waf1 , while decreased the expression levels of cyclin E and p-Rb. |
安全信息
| 危险品标志 | Xi,N |
|---|---|
| 危险类别码 | 37/38-41-50 |
| 安全说明 | 26-39-61 |
| 危险品运输编号 | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| 海关编码 | 2909.50.5000 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-N3059 | 松茋 Pinostilbene | 42438-89-1 | 5mg | 480元 |
| 2025/12/22 | HY-N3059 | 松茋 Pinostilbene | 42438-89-1 | 10mg | 780元 |