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(-)-Irofulven

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Company Name: Zhejiang Huida Biotech Co., LTD  Gold
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Company Name: Shanghai Haozhixiang Biotechnology Co., Ltd  
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(-)-Irofulven Basic information
Product Name:(-)-Irofulven
Synonyms:(R)-Irofulven;Irofulvene;(-)-(HydroxyMethyl)acylfulvene;(6'R)-6'-Hydroxy-3'-(hydroxyMethyl)-2',4',6'-triMethylspiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one;HMAF;MGI 114;NSC 683863;[14C]-Irofulven
CAS:158440-71-2
MF:C15H18O3
MW:246.3
EINECS:
Product Categories:Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:158440-71-2.mol
(-)-Irofulven Structure
(-)-Irofulven Chemical Properties
Melting point 127-129°
alpha D25 -639° (c = 0.096 in ethanol)
storage temp. -20°C
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
form Solid
color Orange
InChIInChI=1S/C15H18O3/c1-8-6-10-12(11(8)7-16)9(2)15(4-5-15)14(3,18)13(10)17/h6,16,18H,4-5,7H2,1-3H3/t14-/m0/s1
InChIKeyNICJCIQSJJKZAH-AWEZNQCLSA-N
SMILESC12([C@](O)(C)C(=O)C3C(=C1C)C(CO)=C(C)C=3)CC2
Safety Information
MSDS Information
(-)-Irofulven Usage And Synthesis
UsesSemi-synrhetic antitumor agent derived from Illudin S. Inhibits DNA synthesis and induces apoptosis in tumor cells. Antineoplastic.
DefinitionChEBI: Irofulven is a member of cyclohexenones.
in vivo

(-)-Irofulven (7 mg/kg; i.p; on days 1-5 and 8-12) produces a statistically significant increase in the median survival of mice bearing tumor cells[2].

Animal Model:Male and female athymic BALB/c mice (nu/nu genotype, 6 weeks old or older) injected with human glioblastoma multiforme[2].
Dosage:7 mg/kg
Administration:i.p; on days 1-5 and 8-12
Result:Was active against all tumor lines.
(-)-Irofulven Preparation Products And Raw materials
Tag:(-)-Irofulven(158440-71-2) Related Product Information
Lathyrol Astaxanthin β,β-Carotene-4,4'-dione, 3,3'-dihydroxy-, (3R,3'R)- illudin M ASTAXANTHIN Spiro[cyclopropane-1,5-[5H]inden]-7(6H)-one, 6-hydroxy-2,4,6-trimethyl-, (6S)- (9CI)