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N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine

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Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:NVP-ACC789
CAS:300842-64-2
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: CONIER CHEM AND PHARMA LIMITED
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Email: sales@conier.com
Products Intro: Product Name:n-(3-bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine
CAS:300842-64-2
Purity:0.99 Package:1kg
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:NVP-ACC789
CAS:300842-64-2
Purity:99.63% Package:10mg;38USD|25mg;53USD|50mg;93USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Career Henan Chemica Co
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Products Intro: Product Name:N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine
CAS:300842-64-2
Purity:Min98%HPLC/LC Package:1g;1USD
Company Name: InvivoChem
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Products Intro: Product Name:ACC-789
CAS:300842-64-2
Purity:98% Package:5mg Remarks:V3414

N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine manufacturers

  • NVP-ACC789
  • NVP-ACC789 pictures
  • $45.00 / 10mg
  • 2026-04-22
  • CAS:300842-64-2
  • Min. Order:
  • Purity: 99.44%
  • Supply Ability: 10g
N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine Basic information
Product Name:N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine
Synonyms:ACC-789; ZK-202650; NVP-ACC-789;ACC789;ACC 789;N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine;Acc-789;ZK 202650;NVP-ACC-789;ACC-789 (NVP-ACC789);N-(3-Bromo-4-methylphenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine;NVP ACC789,Platelet-derived growth factor receptor,inhibit,ZK 202650,PDGFR,NVPACC789,Inhibitor,ZK-202650,ACC789,NVP-ACC789,VEGFR,ACC 789,NVP-ACC-789,Vascular endothelial growth factor receptor
CAS:300842-64-2
MF:C21H17BrN4
MW:405.29
EINECS:
Product Categories:
Mol File:300842-64-2.mol
N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine Structure
N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine Chemical Properties
Boiling point 607.7±55.0 °C(Predicted)
density 1.441
storage temp. Store at -20°C
solubility DMSO:13.0(Max Conc. mg/mL);32.08(Max Conc. mM)
DMF:0.5(Max Conc. mg/mL);1.23(Max Conc. mM)
DMF:PBS (pH 7) (1:10):0.09(Max Conc. mg/mL);0.22(Max Conc. mM)
Ethanol:0.2(Max Conc. mg/mL);0.49(Max Conc. mM)
form A crystalline solid
pka5.46±0.10(Predicted)
color Light yellow to yellow
InChIInChI=1S/C21H17BrN4/c1-14-6-7-16(13-19(14)22)24-21-18-5-3-2-4-17(18)20(25-26-21)12-15-8-10-23-11-9-15/h2-11,13H,12H2,1H3,(H,24,26)
InChIKeyGXWKSXUPEFVUOO-UHFFFAOYSA-N
SMILESC1(NC2=CC=C(C)C(Br)=C2)C2=C(C=CC=C2)C(CC2C=CN=CC=2)=NN=1
Safety Information
MSDS Information
N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine Usage And Synthesis
UsesNVP-ACC789, is an inhibitor of human VEGFR-1, VEGFR-2 (mouse VEGFR-2), VEGFR-3 and PDGFR-β with IC50s of 0.38, 0.02 (0.23), 0.18, 1.4 μM, respectively.
in vivo

NVP-ACC789 which is given in daily oral doses for 6 days blocks VEGF-induced angiogenesis in a dose-dependent manner. NVP-ACC789 also inhibits the response to bFGF to some extent, but the dose-response curve is not linear for NVP-ACC789[1].

IC 50VEGFR-2: 0.02 μM (IC50); VEGFR-1: 0.38 μM (IC50); mVEGFR-2: 0.23 μM (IC50); VEGFR-3: 0.18 μM (IC50); PDGFR-β: 1.4 μM (IC50)
N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine Preparation Products And Raw materials
Tag:N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine(300842-64-2) Related Product Information
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