1160514-60-2
| 中文名称 | 1160514-60-2 |
|---|---|
| 中文同义词 | 化合物 T16687;吡喃 3;化合物PYR3;1-(4-(2,3,3-三氯丙烯酰胺基)苯基)-5-(三氟甲基)-1H-吡唑-4-羧酸乙酯;PYR3,TRPC3通道阻止器;PYR3,TRPC3 CHANNEL BLOCKER;化合物PYR3,10 MM DMSO 溶液;P884294,Pyr3?,1160514-60-2 |
| 英文名称 | 1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid |
| 英文同义词 | 1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid;Pyr3;Ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate;TRPC3 Channel Inhibitor, Pyr3;1-[4-(2,3,3-Trichloro-acryloylamino)-phenyl]-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid ethyl ester;TRPC3 Channel Inhibitor, Pyr3 - CAS 1160514-60-2 - Calbiochem;1H-Pyrazole-4-carboxylic acid, 1-[4-[(2,3,3-trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-, ethyl ester;Pyr3,Pyr-3 |
| CAS号 | 1160514-60-2 |
| 分子式 | C16H11Cl3F3N3O3 |
| 分子量 | 456.63 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1160514-60-2.mol |
| 结构式 |  |
1160514-60-2 性质
| 熔点 | 151-153 °C(Solv: toluene (108-88-3)) |
|---|---|
| 沸点 | 534.0±50.0 °C(Predicted) |
| 密度 | 1.54±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于DMSO（高达40mg/ml）。 |
| 形态 | 粉末 |
| 酸度系数(pKa) | 9.97±0.70(Predicted) |
| 颜色 | 白色至米色 |
| 稳定性 | 可在-20°C下的DMSO中的溶液储存长达3个月。 |
| InChI | 1S/C16H11Cl3F3N3O3/c1-2-28-15(27)10-7-23-25(12(10)16(20,21)22)9-5-3-8(4-6-9)24-14(26)11(17)13(18)19/h3-7H,2H2,1H3,(H,24,26) |
| InChIKey | RZHGONNSASQOAY-UHFFFAOYSA-N |
| SMILES | FC(F)(F)c1[n](ncc1C(=O)OCC)c2ccc(cc2)NC(=O)C(=C(Cl)Cl)Cl |
Pyr3 是 TRPC3 的选择性抑制剂，其对 TRPC3 介导的 Ca2+ 内流的 IC50 值为 700 nM。
IC50: 700 nM (TRPC3).
Pyr3 selectively and directly inhibits TRPC3 channels among TRPC family members. Application of Pyr3 inhibits TRPC3-mediated Ca 2+ influx in a dose-dependent manner with the IC 50 value of 700 nM. Pyr3 becomes apparent at 0.3 μM, and is almost complete at 3 μM. Interestingly, Ca 2+ influx is inhibited by Pyr3 in cells co-expressing TRPC3 plus TRPC6 but not in cells coexpressing TRPC1 plus TRPC5. The Ang II-induced NFAT translocation is suppressed by Pyr3, but weakly by Pyr2 in a concentration-dependent manner (IC 50 value was 0.05 μM for Pyr3 and 2 μM for Pyr2).
安全信息
| WGK Germany | WGK 2 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-108465 | Pyr3 | 1160514-60-2 | 1 mg | 320元 |
| 2026/06/05 | HY-108465 | 1160514-60-2 Pyr3 | 1160514-60-2 | 5mg | 800元 |