| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:CD 3254;3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentaMethyl-2-naphthalenyl)phenyl]-2-propenoicacid
CAS:196961-43-0
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:CD 3254
CAS:196961-43-0
Purity:>=97% by HPLC Remarks:Reach out to us for more information about custom solutions.
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3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoicacid manufacturers
- CD3254
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- $40.00 / 1mg
-
2025-09-30
- CAS:196961-43-0
- Min. Order:
- Purity: 98.71%
- Supply Ability: 10g
- CD3254
-
- $40.00 / 1mg
-
2025-09-30
- CAS:196961-43-0
- Min. Order:
- Purity: 98.71%
- Supply Ability: 10g
|
| | 3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoicacid Basic information |
| Product Name: | 3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoicacid | | Synonyms: | 3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoicacid;CD 3254;2-Propenoic acid, 3-[4-hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-;CD3254,CD-3254;CD3254, 10 mM in DMSO | | CAS: | 196961-43-0 | | MF: | C24H28O3 | | MW: | 364.48 | | EINECS: | | | Product Categories: | | | Mol File: | 196961-43-0.mol | ![3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoicacid Structure](CAS/GIF/196961-43-0.gif) |
| | 3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoicacid Chemical Properties |
| Melting point | 165 - 167°C | | Boiling point | 508.0±50.0 °C(Predicted) | | density | 1.108±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 4.61±0.10(Predicted) | | color | White to Off-White |
| | 3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoicacid Usage And Synthesis |
| Description | CD3254 is a selective agonist of the retinoid X receptors (RXRs; EC50 = ~10 nM for human RXRβ) that is without effect on retinoic acid receptors (RARs). It stimulates the recruitment of the nuclear receptor interaction domain of the TRAP220 coactivator to RXRα/RARβ heterodimers in vitro. CD3254 also enhances the recruitment of the PPARγ coactivator 1α, PGC-1α, to RXRα/PPARγ heterodimers. | | Uses | CD 3254 is a potent RXR agonist. | | storage | Store at -20°C | | References | [1] VIRGINIE NAHOUM. Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 44: 17323-17328. DOI: 10.1073/pnas.0705356104
[2] PETER W. JURUTKA. Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR) Selective Agonists: Novel Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-hydroxyphenyl)acrylic Acid (CD3254)[J]. Journal of Medicinal Chemistry, 2013, 56 21: 8432-8454. DOI: 10.1021/jm4008517
[3] VIVIAN POGENBERG. Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies.[J]. The Journal of Biological Chemistry, 2005, 280 2: 1625-1633. DOI: 10.1074/jbc.m409302200
[4] ALBANE LE MAIRE. Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors.[J]. EMBO Reports, 2009, 10 4: 367-373. DOI: 10.1038/embor.2009.8 |
| | 3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoicacid Preparation Products And Raw materials |
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