|
|
| | 6-Fluoro-1H-pyrrolo[3,2-b]pyridine Basic information |
| | 6-Fluoro-1H-pyrrolo[3,2-b]pyridine Chemical Properties |
| Boiling point | 277.6±20.0 °C(Predicted) | | density | 1.370±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | pka | 14.06±0.40(Predicted) | | Appearance | White to light brown Solid |
| | 6-Fluoro-1H-pyrrolo[3,2-b]pyridine Usage And Synthesis |
| Synthesis | Step 3: To a solution of 5-fluoro-2-((trimethylsilyl)alkynyl)pyridin-3-amine (2.22 g, 10.7 mmol) in N,N-dimethylformamide (DMF, 30 mL) was added sodium hydride (60% Mineral Oil Dispersion, 1.025 g, 42.7 mmol) in one batch at 0 °C and under nitrogen protection. After addition, the reaction mixture was stirred at room temperature for 2 hours. Subsequently, the reaction solution was slowly poured into ice water and extracted with ethyl acetate (EtOAc). The organic phases were combined, dried over anhydrous magnesium sulfate (MgSO), filtered and concentrated under reduced pressure to give 1.46 g of 6-fluoro-1H-pyrrolo[3,2-b]pyridine as a brown solid (100% yield). Mass spectrum (ESI): m/z = 137.2 [M + H] | | References | [1] Patent: WO2013/92940, 2013, A1. Location in patent: Page/Page column 51
[2] Patent: WO2016/103037, 2016, A1. Location in patent: Paragraph 00631 |
| | 6-Fluoro-1H-pyrrolo[3,2-b]pyridine Preparation Products And Raw materials |
|