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| | TP Receptor (mouse) Polyclonal Antibody Basic information |
| | TP Receptor (mouse) Polyclonal Antibody Chemical Properties |
| | TP Receptor (mouse) Polyclonal Antibody Usage And Synthesis |
| Description | The TP receptor is a G protein-coupled receptor that mediates the action of thromboxane A2 (TXA2). Alternative splicing of TP pre-mRNA produces two receptor variants, TPα and TPβ, which differ in sequence and the length of their carboxy terminal tail. TP receptors are expressed primarily in platelets but are also expressed in placenta, vascular smooth muscle, brain, small intestine, thymus, kidney, lung, spleen, and monocytes. It signals in a cell type- and expression-dependent manner and has roles in cardiovascular and hemodynamic function. Tp-/- mice exhibit coagulation defects, altered vascular responses to TXA2 and arachidonic acid, and increased susceptibility to arachidonic acid-induced shock. Cayman’s TP Receptor (mouse) Polyclonal Antibody can be used for Western blot (WB). The antibody recognizes the TPα and TPβ receptors from human, bovine, monkey, mouse, and rat samples. The apparent molecular weight for TP receptors has been reported from 37 kDa to 70 kDa, depending on different degrees of glycosylation. | | References | [1] FRANCESCA SANTILLI Giovanni D Luciana Mucci. TP receptor activation and inhibition in atherothrombosis: the paradigm of diabetes mellitus.[J]. Internal and Emergency Medicine, 2011, 6 3: 203-212. DOI: 10.1007/s11739-010-0440-3
[2] MARCELO H. PETRI . Effects of the dual TP receptor antagonist and thromboxane synthase inhibitor EV-077 on human endothelial and vascular smooth muscle cells[J]. Biochemical and biophysical research communications, 2013, 441 2: Pages 393-398. DOI: 10.1016/j.bbrc.2013.10.078
[3] D W THOMAS. Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2.[J]. Journal of Clinical Investigation, 1998, 102 11: 1994-2001. DOI: 10.1172/jci5116
[4] ALISTER J MCNEISH. Statins and selective inhibition of Rho kinase protect small conductance calcium-activated potassium channel function (K(Ca)2.3) in cerebral arteries.[J]. ACS Applied Bio Materials, 2012: e46735. DOI: 10.1371/journal.pone.0046735 |
| | TP Receptor (mouse) Polyclonal Antibody Preparation Products And Raw materials |
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