| Company Name: |
SPIRO PHARMA |
| Tel: |
|
| Email: |
eric_feng1954@126.com |
- TS-011
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- $64.00
-
2026-07-29
- CAS:339071-18-0
- Purity: 99.95%
- Supply Ability: 10g
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| | (E)-N-(3-chloro-4-Morpholinophenyl)-N'-hydroxyforMiMidaMide Basic information |
| Product Name: | (E)-N-(3-chloro-4-Morpholinophenyl)-N'-hydroxyforMiMidaMide | | Synonyms: | N-(3-Chloro-4-morpholinophenyl);-N'-hydroxyformimidamide;(E)-N-(3-chloro-4-Morpholinophenyl)-N'-hydroxyforMiMidaMide;TS 011;TS-011;N-(3-Chloro-4-morpholinophenyl)-N'-hydroxyformimidamide;N'-(3-chloro-4-morpholin-4-ylphenyl)-n-hydroxymethanimidamide;Methanimidamide, N-[3-chloro-4-(4-morpholinyl)phenyl]-N'-hydroxy- | | CAS: | 339071-18-0 | | MF: | C11H14ClN3O2 | | MW: | 255.70076 | | EINECS: | | | Product Categories: | | | Mol File: | 339071-18-0.mol |  |
| | (E)-N-(3-chloro-4-Morpholinophenyl)-N'-hydroxyforMiMidaMide Chemical Properties |
| Boiling point | 477.8±55.0 °C(Predicted) | | density | 1.37±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMF: 3 mg/ml; DMSO: 2 mg/ml; Ethanol: insol; PBS (pH 7.2): insol | | form | A solid | | pka | 10.99±0.50(Predicted) | | color | White to light brown |
| | (E)-N-(3-chloro-4-Morpholinophenyl)-N'-hydroxyforMiMidaMide Usage And Synthesis |
| Uses | TS 011, is a selective inhibitor of 20-Hydroxyeicosatetraenoic acid synthesis. | | in vivo | TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acidsynthesis. TS-011 at a dose of 0.3 mg/kg inhibits the reduction in the blood flow velocities at 1 and 7 h after reperfusion (P<0.001). In addition, TS-011 inhibits the increase in the blood flow velocity at 24 h after reperfusion (P<0.01). TS-011 protects the microvascular perfusion area from the loss observed in vehicle-treated mice. TS-011, at a dose of 0.3 mg/kg, also reduces the infarct volume by almost 40% (P<0.05)[1]. In 9 dogs with delayed vasospasm, acute blockade of the synthesis of 20-HETE with TS-011 (1 mg/kg IV) significantly increases the diameter of the basilar artery by 39%[2]. |
| | (E)-N-(3-chloro-4-Morpholinophenyl)-N'-hydroxyforMiMidaMide Preparation Products And Raw materials |
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