6-(2-aMinophenoxy)benzo[d]isothiazol-3-aMine

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6-(2-aMinophenoxy)benzo[d]isothiazol-3-aMine manufacturers
6-(2-aMinophenoxy)benzo[d]isothiazol-3-aMine Basic information
Product Name:6-(2-aMinophenoxy)benzo[d]isothiazol-3-aMine
Synonyms:6-(2-aMinophenoxy)benzo[d]isothiazol-3-aMine;M62812 free base
CAS:613262-61-6
MF:C13H11N3OS
MW:257.31094
EINECS:
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Mol File:613262-61-6.mol
6-(2-aMinophenoxy)benzo[d]isothiazol-3-aMine Structure
6-(2-aMinophenoxy)benzo[d]isothiazol-3-aMine Chemical Properties
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MSDS Information
6-(2-aMinophenoxy)benzo[d]isothiazol-3-aMine Usage And Synthesis
UsesM62812 (free base) is a toll-like receptor 4 (TLR4) signal transduction inhibitor. M62812 can suppress endothelial cell and leukocyte activation and prevents lethal septic shock in mice. M62812 can be used for the research of sepsis[1].
in vivo

M62812 (i.v.; 10-20 mg/kg; single) protects mice from lethality and reduced inflammatory and coagulatory parameters in a murine d-galactosamine-sensitized endotoxin shock model[1].
M62812 (20 mg/kg/day) prevents mice from lethality in a murine cecal ligation and puncture model[1].

Animal Model:D-galactosamine-sensitized endotoxin shock mouse model[1]
Dosage:10-20 mg/kg
Administration:Single intravenous administration
Result:Suppressed LPS-induced leukocyte and endothelial cell activation in vivo.
Prolonged survival in a d-galactosamine-sensitized endotoxin shock mouse model.
Animal Model:A cecal ligation and puncture mouse model[1]
Dosage:20 mg/kg
Administration:Intravenous administration; Everyday
Result:Reduced mortality in a murine cecal ligation and puncture model.
References[1] Nakamura M, et al. Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice. Eur J Pharmacol. 2007;569(3):237-243. DOI:10.1016/j.ejphar.2007.05.013
6-(2-aMinophenoxy)benzo[d]isothiazol-3-aMine Preparation Products And Raw materials
Tag:6-(2-aMinophenoxy)benzo[d]isothiazol-3-aMine(613262-61-6) Related Product Information
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