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(6-AMino-5-broMo-pyridin-3-yl)-Methanol manufacturers
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| | (6-AMino-5-broMo-pyridin-3-yl)-Methanol Basic information |
| | (6-AMino-5-broMo-pyridin-3-yl)-Methanol Chemical Properties |
| Boiling point | 344.4±37.0 °C(Predicted) | | density | 1.766±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 13.22±0.10(Predicted) | | Appearance | Light brown to brown Solid |
| | (6-AMino-5-broMo-pyridin-3-yl)-Methanol Usage And Synthesis |
| Synthesis | General procedure for the synthesis of (6-amino-5-bromopyridin-3-yl)methanol from ethyl 6-amino-5-bromonicotinate:
A) Ethyl 6-amino-5-bromonicotinate (2.31 g, 10 mmol) was dissolved in tetrahydrofuran (20 mL) at room temperature and lithium aluminum hydride (LAH, 10 mL, 1 M solution in tetrahydrofuran) was added slowly and dropwise. The reaction mixture was stirred for 1 h. The reaction was quenched by careful addition of water (0.2 mL). The resulting precipitate was collected by filtration and washed with ethyl acetate. The filtrate was concentrated under reduced pressure to give (6-amino-5-bromopyridin-3-yl)methanol (2.0 g, 99% yield) as a white solid. The product was confirmed by LC/MS analysis showing (M + H)+ = 203, 205 (ratio 1:1).1H NMR (CD3OD, 300 MHz) data were as follows: δ 7.79 (s, 1H), 7.67 (s, 1H), 4.35 (br s, 2H). | | References | [1] Patent: WO2008/60907, 2008, A2. Location in patent: Page/Page column 34-35 |
| | (6-AMino-5-broMo-pyridin-3-yl)-Methanol Preparation Products And Raw materials |
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