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MedChemexpress LLC
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021-58955995 |
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| Products Intro: |
Product Name:Pentamidine (dihydrochloride)
CAS:50357-45-4
Purity:>98% Package:651RMB/10mg
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PentaMidine-d4 2HCl manufacturers
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| | PentaMidine-d4 2HCl Basic information |
| Product Name: | PentaMidine-d4 2HCl | | Synonyms: | PentaMidine-d4 2HCl;PentaMidine (dihydrochloride);4,4'-[1,5-Pentanediylbis(oxy)]bisbenzenecarboximidamide] dihydrochloride;Benzenecarboximidamide, 4,4'-[1,5-pentanediylbis(oxy)]bis-, dihydrochloride (9CI);MP601205 dihydrochloride;MP601205 DIHYDROCHLORIDE;PENTAMIDINE;PTP1B,Pneumocystis,Parasite,Antibiotic,antitumor,Pentamidine,MP 601205,Inhibitor,Kidney,MP-601205,carinii,Bacterial,cell-cycle,pneumonia,MP601205,Phosphatase,inhibit,DNA,Pentamidine dihydrochloride,biosynthetics,Fungal,arrest;Pentamidine dihydrochloride, 10 mM in DMSO | | CAS: | 50357-45-4 | | MF: | C19H26Cl2N4O2 | | MW: | 413.34134 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 50357-45-4.mol |  |
| | PentaMidine-d4 2HCl Chemical Properties |
| Melting point | 232-234° | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO > 10 mM | | form | Powder |
| Toxicity | LD50 in mice (mg/g): 0.028 i.v.; 0.064 s.c. (Wein) |
| | PentaMidine-d4 2HCl Usage And Synthesis |
| Uses | Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4]. | | Safety Profile | A poison by subcutaneous and intravenous routes. When heated to decomposition it emits toxic vapors of NOx and HCl. | | in vivo | Pentamidine (0.25 mg/mouse; intramuscular injection; every 2 days; for 4 weeks; athymic nude mice) treatment markedly inhibits the growth of WM9 human melanoma tumors in nude mice[1]. | Animal Model: | Athymic nude mice (6 weeks old) injected with WM9 cells[1] | | Dosage: | 0.25 mg/mouse | | Administration: | Intramuscular injection; every 2 days; for 4 weeks | | Result: | Markedly inhibited the growth of WM9 human melanoma tumors in nude mice.
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| | IC 50 | Trypanosoma; Leishmania | | References | [1] Pathak MK, et al. Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. Mol Cancer Ther. 2002 Dec;1(14):1255-64. PMID:12516958
[2] Nguewa, P.A., et al., Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin. Chem Biodivers, 2005. 2(10): p. 1387-400. DOI:10.1002/cbdv.200590111
[3] Sands M, et al. Pentamidine: a review. Rev Infect Dis. 1985 Sep-Oct;7(5):625-34. DOI:10.1093/clinids/7.5.625
[4] David C. Bean, et al. Pentamidine: a drug to consider re-purposing in the targeted treatment of multi-drug resistant bacterial infections J Lab Precis Med 2017;2:49. |
| | PentaMidine-d4 2HCl Preparation Products And Raw materials |
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