(1-Methyl-2-oxo-1,2-dihydropyridin-4-yl)boronic acid manufacturers
|
| | (1-Methyl-2-oxo-1,2-dihydropyridin-4-yl)boronic acid Basic information |
| Product Name: | (1-Methyl-2-oxo-1,2-dihydropyridin-4-yl)boronic acid | | Synonyms: | (1-Methyl-2-oxo-1,2-dihydropyridin-4-yl)boronic acid;B-(1,2-Dihydro-1-methyl-2-oxo-4-pyridinyl)boronic acid;(1-methyl-2-oxopyridin-4-yl)boronic acid;Boronic acid, B-(1,2-dihydro-1-methyl-2-oxo-4-pyridinyl)-;(1-Methyl-2-oxo-1,2-dihydropyridin-4-yl)boronic acid(contains varying amounts of Anhydride) | | CAS: | 1351413-50-7 | | MF: | C6H8BNO3 | | MW: | 152.94 | | EINECS: | | | Product Categories: | | | Mol File: | 1351413-50-7.mol |  |
| | (1-Methyl-2-oxo-1,2-dihydropyridin-4-yl)boronic acid Chemical Properties |
| Boiling point | 356.2±52.0 °C(Predicted) | | density | 1.30±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | pka | 8.26±0.20(Predicted) | | Appearance | White to yellow Solid |
| | (1-Methyl-2-oxo-1,2-dihydropyridin-4-yl)boronic acid Usage And Synthesis |
| Uses | 1-Methyl-2-oxo-1,2-dihydro-4-pyridinylboronic Acid is an intermediate used to prepare thiazolopyridine ureas as antitubercular agents acting through inhibition of DNA gyrase B. | | Synthesis | (3) The residue from step (2) was dissolved in 1,4-dioxane (500-1000 mL), concentrated hydrochloric acid (500-1000 mL) was added slowly at 25°C and the reaction was stirred for 12 hours. Upon completion of the reaction, the organic phase was separated by extraction using ethyl acetate. The aqueous phase product was concentrated under reduced pressure to remove the solvent to give a white solid product (53.3 g, 60% yield). | | References | [1] Patent: CN106986885, 2017, A. Location in patent: Paragraph 0015; 0016; 0017 |
| | (1-Methyl-2-oxo-1,2-dihydropyridin-4-yl)boronic acid Preparation Products And Raw materials |
|