PF 03382792 manufacturers
- PF-03382792
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- $100.00
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2026-07-27
- CAS:1400811-63-3
- Purity: 99.64%
- Supply Ability: 10g
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| | PF 03382792 Basic information |
| Product Name: | PF 03382792 | | Synonyms: | PF 03382792;6-fluoro-N-((1-((4-hydroxytetrahydro-2H-pyran-4-yl)methyl)piperidin-4-yl)methyl)-3,3-dimethyl-2-oxoindoline-1-carboxamide;6-fluoro-N-[[1-[(4-hydroxyoxan-4-yl)methyl]piperidin-4-yl]methyl]-3,3-dimethyl-2-oxoindole-1-carboxamide;PF-3382792;1H-Indole-1-carboxamide, 6-fluoro-2,3-dihydro-3,3-dimethyl-2-oxo-N-[[1-[(tetrahydro-4-hydroxy-2H-pyran-4-yl)methyl]-4-piperidinyl]methyl]- | | CAS: | 1400811-63-3 | | MF: | C23H32FN3O4 | | MW: | 433.52 | | EINECS: | | | Product Categories: | | | Mol File: | 1400811-63-3.mol |  |
| | PF 03382792 Chemical Properties |
| density | 1.242±0.06 g/cm3(Predicted) | | pka | 11.95±0.40(Predicted) |
| | PF 03382792 Usage And Synthesis |
| Uses | PF-03382792 is a potent 5-HT4 partial agonist with a Ki of 2.7 nM and an EC50 of 0.9 nM for 5-HT4d. PF-03382792 can penetrate the brain. PF-03382792 produces moderate increases in cortical Ach in the rat prefrontal cortex[1]. | | IC 50 | 5-HT4d Receptor: 2.7 nM (Ki); 5-HT4d Receptor: 0.9 nM (EC50) | | References | [1] Michael A Brodney, et al.Identification of multiple 5-HT partial agonist clinical candidates for the treatment of Alzheimer's disease. J Med Chem. 2012 Nov 8;55(21):9240-54. DOI:10.1021/jm300953p |
| | PF 03382792 Preparation Products And Raw materials |
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