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| | MilbeMycin A3 OxiMe Basic information |
| Product Name: | MilbeMycin A3 OxiMe | | Synonyms: | Milbemycin Impurity 10(Milbemycin A3 Oxime);MilbeMycin A3 OxiMe;5-OxoMilbeMycin A3 oxiMe;5-ketomilbemycin A3 5-oxime;Milbemycin B, 5-demethoxy-28-deoxy-6,28-epoxy-5-(hydroxyimino)-25-methyl-, (6R,25R)-;Milbemite Impurity 2;Milbexime impurity 11;(1R,4S,5'S,6R,6'R,8R,10E,13R,14E,16E,20R,24S)-24-hydroxy-21-hydroxyimino-5',6',11,13,22-pentamethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one | | CAS: | 114177-14-9 | | MF: | C31H43NO7 | | MW: | 541.68 | | EINECS: | | | Product Categories: | | | Mol File: | 114177-14-9.mol |  |
| | MilbeMycin A3 OxiMe Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml | | form | A crystalline solid |
| | MilbeMycin A3 OxiMe Usage And Synthesis |
| Description | Milbemycin A3 oxime is an anthelmintic, a derivative of milbemycin A3 , and a component of milbemycin oxide . It reduces the number of microfilariae of the heartworm D. immitis in the blood of naturally infested dogs by 85.2% when administered at a dose of 0.05 mg/kg. Formulations containing milbemycin A3 oxime, in combination with milbemycin A4 oxime, have been used in the treatment of parasitic infections in dogs. | | Uses | Milbemycin A3 oxime is a semi-synthetic macrocyclic lactone prepared by the oxidation and oximation of a mixture of milbemycin A3. Milbemycin A3 oxime is the minor component (~30%) in the commercial product milbemycin oxime, marketed for endo- and exo-parasite infections. Like the other milbemycin/avermectins, milbemycin A3 oxime acts by opening glutamate sensitive chloride channels in neurons of invertebrates leading to paralysis by hyperpolarisation of these cells and signal transfer blocking. | | Uses | Milbemycin A3 oxime is the minor component of the anti-parasitic product milbemycin oxime. | | References | [1] Y TSUKAMOTO. Synthesis of 5-keto-5-oxime derivatives of milbemycins and their activities against microfilariae.[J]. Agricultural and biological chemistry, 1991, 55 10: 2615-2621.
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| | MilbeMycin A3 OxiMe Preparation Products And Raw materials |
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