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Musechem |
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+1-800-259-7612 |
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info@musechem.com |
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BOC Sciences |
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16314854226; +8616314854226 |
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inquiry@bocsci.com |
Adapalene (sodiuM salt) manufacturers
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| | Adapalene (sodiuM salt) Basic information |
| | Adapalene (sodiuM salt) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | ≥ 4.35mg/mL in DMSO with gentle warming |
| | Adapalene (sodiuM salt) Usage And Synthesis |
| Uses | Adapalene (CD271) sodium salt, a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene sodium salt is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene sodium salt also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene sodium salt exhibits anti-tumor activity[1][2][3]. | | in vivo | Adapalene sodium salt (15-100 mg/kg; p.o. daily for 21 days) inhibits the growth of DLD1 cell-derived xenograft tumors in BALB/C nude mice[3]. | Animal Model: | Female BALB/C nude mice (15 g, 4-5 weeks) were injected with DLD1 cells[3] | | Dosage: | 15, 20, 65, 100 mg/kg | | Administration: | P.o. daily for 21 days | | Result: | Significantly reduced tumor weight and volume.
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| | References | [1] Shroot B, et, al. Pharmacology and chemistry of adapalene. J Am Acad Dermatol. 1997 Jun;36(6 Pt 2):S96-103. DOI:10.1016/s0190-9622(97)70050-1
[2] Wang Q, et, al. Adapalene inhibits ovarian cancer ES-2 cells growth by targeting glutamic-oxaloacetic transaminase 1. Bioorg Chem. 2019 Dec;93:103315. DOI:10.1016/j.bioorg.2019.103315
[3] Shi XN, et, al. Adapalene inhibits the activity of cyclin-dependent kinase 2 in colorectal carcinoma. Mol Med Rep. 2015 Nov;12(5):6501-8. DOI:10.3892/mmr.2015.4310 |
| | Adapalene (sodiuM salt) Preparation Products And Raw materials |
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