1047659-02-8
| 中文名称 | 1047659-02-8 |
|---|---|
| 中文同义词 | 恩他卡朋钠盐;(E)-2-氰基-3-(3,4-二羟基-5-硝基苯)-N,N二乙基丙烯酰胺钠盐;化合物 T11207 |
| 英文名称 | Entacapone (sodiuM salt) |
| 英文同义词 | Entacapone (sodiuM salt);Entacapone Sodium;Sodium (E)-4-(2-cyano-3-(diethylamino)-3-oxoprop-1-en-1-yl)-2-hydroxy-6-nitrophenolate |
| CAS号 | 1047659-02-8 |
| 分子式 | C14H14N3NaO5 |
| 分子量 | 329.29 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1047659-02-8.mol |
| 结构式 |  |
1047659-02-8 性质
| 溶解度 | 溶于二甲基亚砜 |
|---|---|
| 形态 | 粉末 |
IC50: 10 nM (rat brain COMT); 20 nM (rat erythrocyte COMT); 160 nM (rat liver COMT)
Entacapone sodium salt (50 μM, 48 hours) enhances the amount of m6A on mRNA in Hep-G2 cells. It does not show any inhibitory effect on the enzymatic activity of the RNA m6A demethylase AlkB homolog 5 (ALKBH5) or the ten-eleven translocation methylcytosine dioxygenase 1 (TET1), nor does it alter the DNA methylation or histone methylation patterns in Entacapone sodium salt -treated Hep-G2 cells.
Entacapone sodium salt (oral administration; 600 mg/kg per day; 3-9 weeks) results in a dose-response effect dose-response effect. After 3 weeks, mouse body weight are decreased by 10.1% compared to controls, and shows similar food intake fat mass and fat mass ratio reduced after Entacapone sodium salt treatment. Entacapone sodium salt also increases the energy expenditure of mice: reductions in total cholesterol (17.6%), low-density lipoprotein cholesterol (31.0%), and triglycerides (10.2%) in mice.