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| | 2-Pyridinecarboxylic acid,6-bromo-3-methoxy- Basic information |
| | 2-Pyridinecarboxylic acid,6-bromo-3-methoxy- Chemical Properties |
| Boiling point | 372.5±42.0 °C(Predicted) | | density | 1.713±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 3.14±0.10(Predicted) | | Appearance | Off-white to brown Solid | | InChI | InChI=1S/C7H6BrNO3/c1-12-4-2-3-5(8)9-6(4)7(10)11/h2-3H,1H3,(H,10,11) | | InChIKey | KRGGGVKGKFLABG-UHFFFAOYSA-N | | SMILES | C1(C(O)=O)=NC(Br)=CC=C1OC |
| | 2-Pyridinecarboxylic acid,6-bromo-3-methoxy- Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 6-bromo-3-methoxy-2-pyridinecarboxylic acid from methyl 6-bromo-3-methoxypyridinecarboxylate: Methyl 6-bromo-3-methoxypyridinecarboxylate (4 g, 18.4 mmol) and lithium hydroxide monohydrate (LiOH-H2O, 1.6 g, 36.9 mmol) were reacted in a solvent mixture of dioxane/water (5:1, 40 mL) at room temperature. The reaction was stirred overnight at room temperature. After completion of the reaction, the pH of the reaction solution was adjusted to 7 with dilute hydrochloric acid, and the precipitate was collected by filtration to afford the crude product 6-bromo-3-methoxy-2-pyridinecarboxylic acid (3.1 g, yield: 81%). The product was confirmed by nuclear magnetic resonance hydrogen spectroscopy (1H NMR, CDCl3, 400 MHz): δ 10.71 (m, 1H), 7.70 (d, J = 8.0 Hz, 1H), 7.40 (d, J = 8.0 Hz, 1H), 4.01 (s, 3H). Mass spectrometry (MS) analysis showed the molecular ion peak (M + H)+: 232/234. | | References | [1] Patent: WO2014/121418, 2014, A1. Location in patent: Page/Page column 45
[2] Patent: WO2007/31558, 2007, A1. Location in patent: Page/Page column 32
[3] Patent: WO2014/209727, 2014, A1. Location in patent: Page/Page column 39-40
[4] Patent: WO2014/205593, 2014, A1. Location in patent: Page/Page column 42 |
| | 2-Pyridinecarboxylic acid,6-bromo-3-methoxy- Preparation Products And Raw materials |
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