| Company Name: |
Suzhou Zhixin Biotechnology Co., Ltd. Gold
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| Tel: |
0512-65118909 18100677375 |
| Email: |
sales@szzxbio.com |
| Products Intro: |
Product Name:BI6015
CAS:93987-29-2
Purity:98%+ Package:1g;10g;100g
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| | BI 6015 Basic information |
| Product Name: | BI 6015 | | Synonyms: | BI 6015;2-Methyl-1-(2-methyl-5-nitrophenylsulfonyl)-1H-benzo[d]imidazole;2-Methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole;inhibit,promoter,HNF4α,factor,hepatocyte,Inhibitor,diabetes,insulin,BI-6015,BI6015,nuclear,cancer,BI 6015;1H-Benzimidazole, 2-methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-;B16015;BI-6015, 10 mM in DMSO;HNF4 Antagonist, BI6015 | | CAS: | 93987-29-2 | | MF: | C15H13N3O4S | | MW: | 331.35 | | EINECS: | | | Product Categories: | Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds | | Mol File: | 93987-29-2.mol |  |
| | BI 6015 Chemical Properties |
| Boiling point | 570.6±60.0 °C(Predicted) | | density | 1.45±0.1 g/cm3(Predicted) | | storage temp. | +2C to +8C | | solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml). | | form | Beige powder | | pka | 0.88±0.10(Predicted) | | color | Tan | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. | | InChI | InChI=1S/C15H13N3O4S/c1-10-7-8-12(18(19)20)9-15(10)23(21,22)17-11(2)16-13-5-3-4-6-14(13)17/h3-9H,1-2H3 | | InChIKey | ILVCPQPMRPHZSG-UHFFFAOYSA-N | | SMILES | C1(C)N(S(C2=CC([N+]([O-])=O)=CC=C2C)(=O)=O)C2=CC=CC=C2N=1 |
| | BI 6015 Usage And Synthesis |
| Description | BI-6015 (93987-29-2) is a hepatocyte nuclear factor 4α (HNF4α) antagonist. HNF4α is a central regulator of gene expression in cell types that play a central role in metabolic homeostasis.1 BI-6015 binds to HNF4α with high affinity and modulates the expression of known target genes. It was shown to be selectively cytotoxic to cancer cell lines in vitro and in vivo however in vivo potency was limited by suboptimal pharmacokinetics.2 BI-6015 represents the first small molecule tool for pharmacologic modulation of HNF4α activity.2 Cell permeable. | | Uses | BI 6015 is a known HNF4α antagonist that represses the expression of known HNF4α target genes. Studies have shown that BI6015 are also capable of exhibiting selective cytotoxic activities against numerous tumor cell lines. | | in vivo | BI-6015 (10-30 mg/kg; i.p. once daily for 5 days) induces loss of HNF4α expression and hepatic steatosis in mice[1].
BI-6015 (10-30 mg/kg; i.p. daily or every other day for 20-57 days) induces apoptosis in a human hepatocellular carcinoma mouse model[1].
| | storage | Store at -20°C | | References | [1] H WANG. Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretion.[J]. The Journal of Biological Chemistry, 2000, 275 46: 35953-35959. DOI:10.1074/jbc.m006612200
[2] ALICE KISELYUK. HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter.[J]. Chemistry & biology, 2012: 806-818. DOI:10.1016/j.chembiol.2012.05.014 |
| | BI 6015 Preparation Products And Raw materials |
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