1198768-91-0
| 中文名称 | 1198768-91-0 |
|---|---|
| 中文同义词 | 化合物 ESOMEPRAZOLE MAGNESIUM SALT |
| 英文名称 | EsoMeprazole (MagnesiuM salt) |
| 英文同义词 | EsoMeprazole (MagnesiuM salt) |
| CAS号 | 1198768-91-0 |
| 分子式 | C17H21MgN3O3S |
| 分子量 | 371.74 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1198768-91-0.mol |
| 结构式 |  |
1198768-91-0 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 粉末 |
Esomeprazole magnesium salt ((S)-Omeprazole magnesium salt) 是一种有效的具有口服活性质子泵抑制剂，可通过抑制胃壁细胞中的 H+, K+-ATPase 来降低酸分泌，并可用于胃食管反流疾病的研究。
H + , K + -ATPase
Esomeprazole (25-100 µM; 20 hours; MDA-MB-468 cells) treatment suppresses growth of triple-negative breast cancer cell in vitro in a dose-dependent manner through increase in their intracellular acidification.
Cell Viability Assay
| Cell Line: | MDA-MB-468 cells |
| Concentration: | 25 µM, 50 µM, 75 µM, 100 µM |
| Incubation Time: | 20 hours |
| Result: | Suppressed growth of triple-negative breast cancer cell in vitro in a dose-dependent manner. |
Esomeprazole (30-300 mg/kg; oral gavage; daily; for 19 or 11 days; C57BL/6J mice) treatment significantly inhibits the progression of fibrosis throughout the lungs of the animals. Esomeprazole also reduces circulating markers of inflammation and fibrosis.
| Animal Model: | C57BL/6J mice (8-weeks old, 25-30 g) treated with cotton smoke-induced lung injury |
| Dosage: | 30 mg/kg, 300 mg/kg |
| Administration: | Oral gavage; daily; for 19 or 11 days |
| Result: | Significantly inhibited the progression of fibrosis throughout the lungs of the animals. |