| Company Name: |
Cool Pharm, Ltd |
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021-58581007 18019463053 |
| Email: |
sales@coolpharm.com |
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| | (5-Ethylisoxazol-3-yl)amine Basic information |
| | (5-Ethylisoxazol-3-yl)amine Chemical Properties |
| Melting point | 71-72℃ | | Boiling point | 243.8±20.0 °C(Predicted) | | density | 1.115±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 2.41±0.10(Predicted) |
| | (5-Ethylisoxazol-3-yl)amine Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 3-amino-5-ethylisoxazole from 3-oxovaleronitrile: A portion of the resulting product (0.6 g) was taken and mixed with hydrazine hydrate (0.28 ml) and ethanol (45 ml), and the reaction was heated for 12 hr at 70 °C. After completion of the reaction, the solvent was removed by evaporation and the resulting residue was purified by silica gel column chromatography, using a solvent mixture of dichloromethane and methanol (19:1, v/v) as eluent. The target product 3-amino-5-ethylisoxazole was finally obtained in 51% yield. The product was characterized by 1H NMR (solvent DMSO-d6): δ 1.04 (t, 3H), 2.41 (q, 2H), 4.4 (br s, 2H). | | References | [1] Patent: US2009/76075, 2009, A1. Location in patent: Page/Page column 38
[2] Patent: EP2773638, 2015, B1. Location in patent: Paragraph 1189; 1190 |
| | (5-Ethylisoxazol-3-yl)amine Preparation Products And Raw materials |
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