2-(4-[1,3-Benzodioxol-5-ylmethyl]-1-piperazinyl)pyrimidine maleate salt manufacturers
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| | 2-(4-[1,3-Benzodioxol-5-ylmethyl]-1-piperazinyl)pyrimidine maleate salt Basic information |
| | 2-(4-[1,3-Benzodioxol-5-ylmethyl]-1-piperazinyl)pyrimidine maleate salt Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: >10mg/mL
H2O: >10mg/mL | | form | powder | | InChI | 1S/C16H18N4O2.C4H4O4/c1-4-17-16(18-5-1)20-8-6-19(7-9-20)11-13-2-3-14-15(10-13)22-12-21-14;5-3(6)1-2-4(7)8/h1-5,10H,6-9,11-12H2;1-2H,(H,5,6)(H,7,8)/b;2-1- | | InChIKey | DKGOFBARSQSLOW-BTJKTKAUSA-N | | SMILES | [H]\C(=C(/[H])C(O)=O)C(O)=O.C1Oc2ccc(CN3CCN(CC3)c4ncccn4)cc2O1 |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 2-(4-[1,3-Benzodioxol-5-ylmethyl]-1-piperazinyl)pyrimidine maleate salt Usage And Synthesis |
| Uses | Piribedil maleate is a potent and orally active dopamine D2 and dopamine D3 agonist. Piribedil maleate is also a α2-adrenoceptors antagonist. Piribedil maleate can inhibit MLL1 methyltransferase activity (EC50: 0.18 μM). Piribedil maleate has the potential for the research of parkinson's disease, circulatory disorders, cancers[1][2][3][4]. | | Biological Activity | A direct dopamine agonist; may be selective for the D3 subtype; no significant affinity for D1 receptors. | | References | [1] Sweet RD, et al. Piribedil, a dopamine agonist, in Parkinson's disease. Clin Pharmacol Ther. 1974 Dec;16(6):1077-82. DOI:10.1002/cpt19741661077
[2] Gerlach M, et al. The effect of piribedil on L-DOPA-induced dyskinesias in a rat model of Parkinson's disease: differential role of α(2) adrenergic mechanisms. J Neural Transm (Vienna). 2013 Jan;120(1):31-6. DOI:10.1007/s00702-012-0818-7
[3] Smith LA, Tet al. Repeated administration of piribedil induces less dyskinesia than L-dopa in MPTP-treated common marmosets: a behavioural and biochemical investigation. Mov Disord. 2002 Sep;17(5):887-901. DOI:10.1002/mds.10200
[4] Xiong Zhang, et al. Piribedil disrupts the MLL1-WDR5 interaction and sensitizes MLL-rearranged acute myeloid leukemia (AML) to doxorubicin-induced apoptosis. Cancer Lett. 2018 Sep 1;431:150-160. DOI:10.1016/j.canlet.2018.05.034 |
| | 2-(4-[1,3-Benzodioxol-5-ylmethyl]-1-piperazinyl)pyrimidine maleate salt Preparation Products And Raw materials |
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