| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
Thiazolidine,3-[(2S,3S)-2-aMino-3-Methyl-1-oxopentyl]-, (2E)-2-butenedioate (2:1) manufacturers
|
| | Thiazolidine,3-[(2S,3S)-2-aMino-3-Methyl-1-oxopentyl]-, (2E)-2-butenedioate (2:1) Basic information |
| | Thiazolidine,3-[(2S,3S)-2-aMino-3-Methyl-1-oxopentyl]-, (2E)-2-butenedioate (2:1) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | ≤1mg/ml in ethanol;15mg/ml in DMSO;5mg/ml in dimethyl formamide | | form | crystalline solid |
| | Thiazolidine,3-[(2S,3S)-2-aMino-3-Methyl-1-oxopentyl]-, (2E)-2-butenedioate (2:1) Usage And Synthesis |
| Uses | P32/98 is a dipeptidyl peptidase IV inhibitor which is used in hypertensive patients treated with antihpertensive drugs. | | Biological Activity | ki: 126 nmp32/98 (hemifumarate) is an inhibitor of dpp iv.glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide 1 (glp-1) are responsible for >50% of nutrient-stimulated insulin secretion. after being released into the circulation, gip and glp-1 are quickly inactivated by the circulating enzyme dipeptidyl peptidase iv (dpp iv). | | in vitro | p32/98 was found to be able to block adipogenesis dose-dependently, starting at the concentration of 100 μm, and p32/98 could completely block adipogenesis in 3t3-l1 cell line at 500 μm concentration. in addition, the inhibitory effects of p32/98 was further confirmed by detecting the expression of adipocyte markers at the end of differentiation [1]. | | in vivo | in previou animal study, two groups of fa/fa zucker rats were orally treated twice daily for three months with p32/98 at 20 mg/kg/day and monthly oral glucose tolerance tests (ogtts) were conducted after drug washout. results showed that after 12 weeks of p32/98 treatment, the peak ogtt blood glucose values in the treated rats averaged 8.5 mmol/l less than in the controls. in addition, the concomitant insulin resulted in an increased early-phase insulin response in the treated group. moreover, in response to an 8.8 mmol/l glucose perfusion, pancreata from controls showed no increase in insulin secretion, while pancreata from p32/98-treated animals had a 3.2-fold rise in insulin secretion [2]. | | IC 50 | DPP-4: 130 nM (Ki) | | references | 1. han r, wang x, bachovchin w, zukowska z, osborn jw. inhibition of dipeptidyl peptidase 8/9 impairs preadipocyte differentiation. sci rep. 2015 aug 5;5:12348. 2. j. a. pospisilik, s. g. stafford, h. u. demuth, et al. long-term treatment with the dipeptidyl peptidase iv inhibitor p32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and β-cell glucose responsiveness in vdf (fa/fa) zucker rats. diabetes 51, 943-950 (2002). |
| | Thiazolidine,3-[(2S,3S)-2-aMino-3-Methyl-1-oxopentyl]-, (2E)-2-butenedioate (2:1) Preparation Products And Raw materials |
|