4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid
概述 用途与合成方法 MSDS 4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid价格(试剂级) 上下游产品信息
| 中文名称 | 4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid |
|---|---|
| 中文同义词 | 化合物SR 1664;SR 1664,PPARΓ配体;化合物SR 1664,10 MM DMSO 溶液;(S)-4'-((2,3-二甲基-5-((1-(4-硝基苯基)乙基)氨基甲酰基)-1H-吲哚-1-基)甲基)-[1,1'-联苯基]-2-甲酸 |
| 英文名称 | 4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid |
| 英文同义词 | 4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid;SR1664;IIJDFXNUWZTHIM-NRFANRHFSA-N;[1,1'-Biphenyl]-2-carboxylic acid, 4'-[[2,3-dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]-;SR1664 >=98% (HPLC);Inhibitor,inhibit,HEK293T,F282,clash,SR1664,stereospecificity,PPAR,dependent,phosphorylation,SR-1664,S273,Peroxisome proliferator-activated receptors;SR1664, 10 mM in DMSO;(S)-4'-((2,3-Dimethyl-5-((1-(4-nitrophenyl)ethyl)carbamoyl)-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid |
| CAS号 | 1338259-05-4 |
| 分子式 | C33H29N3O5 |
| 分子量 | 547.6 |
| EINECS号 | |
| 相关类别 | 库存 |
| Mol文件 | 1338259-05-4.mol |
| 结构式 | ![4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid 结构式](CAS/20200611/GIF/1338259-05-4.gif) |
4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid 性质
| 沸点 | 828.8±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.27±0.1 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | DMSO：可溶15mg/mL，澄清 |
| 酸度系数(pKa) | 3.87±0.36(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| InChIKey | IIJDFXNUWZTHIM-NRFANRHFSA-N |
| SMILES | [N+](=O)([O-])c1ccc(cc1)[C@@H](NC(=O)c2cc3c([n](c(c3C)C)Cc4ccc(cc4)c5c(cccc5)C(=O)O)cc2)C |
4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid 用途与合成方法
SR1664是一种 PPARγ 拮抗剂。SR1664能结合 PPARγ，并有效抑制 Cdk5 介导的 PPARγ 磷酸化 (IC50=80 nM; Ki= 28.67 nM)。
安全信息
| 危险类别码 | 53 |
|---|---|
| WGK Germany | 3 |
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-12483 | SR1664 | 1338259-05-4 | 1 mg | 636元 |
| 2025/12/22 | HY-12483 | 4′-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]- [1,1′-Biphenyl]-2-carboxylic acid SR1664 | 1338259-05-4 | 5 mg | 1400元 |