N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide

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N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide manufacturers

  • CYM-5541
  • CYM-5541 pictures
  • $52.00
  • 2026-06-02
  • CAS:945128-26-7
  • Purity: 99.76%
  • Supply Ability: 10g
N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide Basic information
Product Name:N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide
Synonyms:CYM5541;CYM-5541;ML249;N,N-Dicyclohexyl(5-cyclopropylisoxazol-3-yl)-carboxamide;N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide;CYM 5541(ML-249);CYM-5541;CYM 5541;ML-249;ML 249;ML249;N,N-dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide
CAS:945128-26-7
MF:C19H28N2O2
MW:316.44
EINECS:
Product Categories:
Mol File:945128-26-7.mol
N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide Structure
N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide Chemical Properties
Boiling point 503.1±38.0 °C(Predicted)
density 1.14±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble5mg/mL, clear (warmed)
form powder
pka-2.57±0.20(Predicted)
color white to beige
Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChI1S/C19H28N2O2/c22-19(17-13-18(23-20-17)14-11-12-14)21(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h13-16H,1-12H2
InChIKeyNDKGACIWVAOUQH-UHFFFAOYSA-N
SMILESN(C4CCCCC4)(C3CCCCC3)C(=O)c1n[o]c(c1)C2CC2
Safety Information
Hazard Codes Xn
Risk Statements 22
WGK Germany 3
Storage Class11 - Combustible Solids
Hazard ClassificationsAcute Tox. 4 Oral
MSDS Information
N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide Usage And Synthesis
DescriptionThe sphingosine 1-phosphate (S1P) receptor S1P3 has roles in vasodilation, epithelial barrier function, cardioprotection, fibrosis, immunity, and inflammation. CYM 5541 is a selective, allosteric agonist of S1P3 (EC50 = 72-132 nM). It less effectively activates S1P1 (EC50 = 28-38 μM) and is ineffective at S1P2, S1P4, and S1P5 as well as a panel of other receptors, ion channels and transporters.
UsesCYM 5541, is a selective allosteric agonist of SAR and S1P3 receptors.
Biochem/physiol ActionsCYM-5541 is an allosteric agonist selective for the Sphingosine 1-phosphate (S1P) S1P3 receptor subtype. CYM-5541 occupies a different chemical space in the ligand binding pocket of S1P3 than S1P does, a lower hydrophobic region around transmembrane helix TM6. CYM-5541 shows great selectivity and stability with an EC50 of between 72 and 132 nM compared to S1P1 EC50 > 10 μM, S1P2 EC50 > 50 μM, S1P4 EC50 > 50 μM, and S1P5 EC50 > 25 μM and no significant activities for a panel of 55 GPCRs, ion channels, and transporters.
storageStore at +4°C
References[1] Probe Development Efforts for an Allosteric Agonist of Sphingosine 1-phosphate Receptor 3 (S1P3); Probe Reports from the NIH Molecular Libraries Program
[2] EUIJUNG JO. Novel Selective Allosteric and Bitopic Ligands for the S1P3 Receptor[J]. ACS Chemical Biology, 2012, 7 12: 1975-1983. DOI:10.1021/cb300392z
N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide Preparation Products And Raw materials
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