- 5-Bromo-2-iodopyrimidine
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- $0.00 / 1KG
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2026-04-22
- CAS:183438-24-6
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 30tons/month
- 5-Bromo-2-iodopyrimidine
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- $1.10 / 1g
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2025-11-18
- CAS:183438-24-6
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons Min
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| | 5-Bromo-2-iodopyrimidine Basic information |
| | 5-Bromo-2-iodopyrimidine Chemical Properties |
| Melting point | 99-103 °C (lit.) | | Boiling point | 341.0±34.0 °C(Predicted) | | density | 2.495±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | Crystalline Powder | | pka | -2.56±0.22(Predicted) | | color | White to tan | | Sensitive | Light Sensitive | | InChI | InChI=1S/C4H2BrIN2/c5-3-1-7-4(6)8-2-3/h1-2H | | InChIKey | ZEZKXPQIDURFKA-UHFFFAOYSA-N | | SMILES | C1(I)=NC=C(Br)C=N1 | | CAS DataBase Reference | 183438-24-6(CAS DataBase Reference) |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-36/38-36/37/38 | | Safety Statements | 26-37/39-37 | | WGK Germany | 3 | | HazardClass | IRRITANT, LIGHT SENSITIVE | | HS Code | 29309090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2 |
| | 5-Bromo-2-iodopyrimidine Usage And Synthesis |
| Chemical Properties | White solid | | Uses | 5-Bromo-2-iodopyrimidine can be used to synthesize 5,5′-dibromo-2,2′-bipyrimidine and O,O′-dimethyl hyrtinadine A. | | General Description | 5-Bromo-2-iodopyrimidine can be synthesized by reacting 5-bromo-2-chloropyrimidine with hydroiodic acid. | | Synthesis | General procedure for the synthesis of 5-bromo-2-iodopyrimidine from 5-bromo-2-chloropyrimidine: 5-bromo-2-chloropyrimidine (5.80 g, 30 mmol) and sodium iodide (7.5 g, 50 mmol) were suspended in chloroform (20 mL), and hydriodic acid (57 wt%, 2.85 g, 25.6 mmol) was slowly added at 0 °C. After cooling was withdrawn, the reaction mixture was stirred at room temperature for 20 hours. Subsequently, the reaction mixture was poured into a mixture of 200 mL of ice water with 30 mL of 10 N sodium hydroxide solution. Chloroform (150 mL) was added and stirred for 10 minutes. The organic phase was separated and the aqueous layer was extracted with chloroform (2 x 100 mL). The organic phases were combined, dried over anhydrous magnesium sulfate, and concentrated in vacuo to give 5-bromo-2-iodopyrimidine as a light yellow solid. Yield: 6.29 g (84%). Mass spectrum (MS): M = 284.8 (ESI+). 1H-NMR (300 MHz, CDCl3): δ 8.54 (s, 2H), 7.56 (d, J = 16.4 Hz, 1H), 7.59-7.66 (m, 4H). | | References | [1] Angewandte Chemie - International Edition, 1999, vol. 38, # 5, p. 659 - 661
[2] Patent: US2005/222228, 2005, A1. Location in patent: Page/Page column 15-16
[3] Chemical Communications, 1996, # 24, p. 2719 - 2720
[4] Patent: US2012/238751, 2012, A1. Location in patent: Page/Page column 30
[5] Patent: WO2014/43272, 2014, A1. Location in patent: Paragraph 0411; 0412; 0413 |
| | 5-Bromo-2-iodopyrimidine Preparation Products And Raw materials |
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